{"id":315,"date":"2024-06-15T11:31:35","date_gmt":"2024-06-15T02:31:35","guid":{"rendered":"https:\/\/mors01.co.kr\/?p=315"},"modified":"2024-06-15T11:31:35","modified_gmt":"2024-06-15T02:31:35","slug":"%eb%85%b8%ed%99%94%ec%9d%98-%ec%a2%85%eb%a7%90-%eb%8d%b0%ec%9d%b4%eb%b9%84%eb%93%9c-%ec%8b%b1%ed%81%b4%eb%a0%88%ec%96%b4","status":"publish","type":"post","link":"https:\/\/mors01.co.kr\/?p=315","title":{"rendered":"\ub178\ud654\uc758 \uc885\ub9d0 – \ub370\uc774\ube44\ub4dc \uc2f1\ud074\ub808\uc5b4"},"content":{"rendered":"\n

\ub178\ud654\uc758 \uc885\ub9d0 – \ub370\uc774\ube44\ub4dc \uc2f1\ud074\ub808\uc5b4<\/strong>
@ \uae30\ubd84 \uc88b\uc740 \ucda9\uaca9\uc744 \uc120\uc0ac\ud558\ub294 \ucc45\uc774\ub2e4. \ub2f9\uc5f0\ud558\uac8c \uc0dd\uac01\ud588\ub358 ‘\ub178\ud654’\uc5d0 \ub300\ud55c \uc0dd\uac01\uc744 \ubc14\uafb8\uac8c \ub410\ub2e4. \ub299\uace0 \ubcd1\ub4e4\uc5b4 \uac00\ub294 \uac74 \ub2f9\uc5f0\ud55c \uc77c\uc774\ub77c\uace0 \uc0dd\uac01\ud588\ub294\ub370, \uc0dd\uac01\ubcf4\ub2e4 \uc608\ubc29\ud560 \ubc29\ubc95\uc774 \ub9ce\ub2e4\uace0 \ub290\uaf08\ub2e4. \uc544\uc9c1 \uc80a\uc740 \ub0a0\uc5d0 \uc774\ub7f0 \uae00\uc744 \uc77d\uac8c \ub418\uc5c8\uc74c\uc5d0 \uac10\uc0ac\ud55c\ub2e4.
\uac00\uc7a5 \ucda9\uaca9\uc801\uc778 \ubd80\ubd84\uc740 \ub178\ud654\uc758 \uc774\ub860\uc774\uc5c8\ub2e4. \uc138\ud3ec\uac00 \ubcf5\uc81c\ub418\uba74\uc11c \uc77c\uc5b4\ub098\ub294 \uc815\ubcf4\uc758 \uc190\uc2e4 \ub54c\ubb38\uc5d0 \ub299\ub294\ub2e4\ub294 \uc0ac\uc2e4. \uadf8\uac83\uc744 \uc6d0\ucd08\uc9c1\uc778 \uc720\uc804\uc790 A\uc640 \uc720\uc804\uc790 B\ub85c \ub098\ub204\uc5b4 \uc124\uba85\ud558\ub294 \uac8c \uc778\uc0c1\uae4a\uc5c8\uc74c.<\/p>\n\n\n\n

. \uc790\uc5f0\uc0ac\ub294 \uc5c6\ub2e4.  \uacb0\uad6d \ub299\uc5b4\uc11c \uc5b4\ub518\uac00 \uace0\uc7a5\uc774 \ub098\uc11c \uc8fd\ub294\ub2e4. \uc8fd\uc74c\uc740 \uc808\ub300\ub85c \ud3c9\ud654\ub86d\uc9c0 \uc54a\uc73c\uba70, \uc624\ud788\ub824 \ud3ed\ub825\uc801\uc774\ub2e4. [\uc791\uac00\ub294 \uc5ec\uae30\uc11c \ub180\ub77c\uc6b4 \uc9c8\ubb38\uc744 \ub358\uc9c4\ub2e4. \uc6b0\ub9ac\uac00 \ub354 \uc80a\uac8c \ub354 \uc624\ub798 \uc0b4 \uc218 \uc788\ub2e4\uba74? \uc0dd\uc560\uc758 \ub9d0\ub144\uc774 \uc55e\uc11c \uc0b0 \uc5ec\ub7ec \ud574\ub4e4\uacfc \uadf8\ub2e4\uc9c0 \ub2e4\ub974\uc9c0 \uc54a\uc544 \ubcf4\uc778\ub2e4\uba74? \uc2dc\uac04\uc774 \ud758\ub7ec\uac10\uc744 \uac71\uc815\ud558\uc9c0 \uc54a\uace0, \uc544\uc774\ucc98\ub7fc \ub354 \uc624\ub798 \uc9c0\ub0bc \uc218 \uc788\ub2e4\uba74? ]
.\uc0b6\uc744 \uc5f0\uc7a5\ud558\ub294 \uac83\uacfc \ud65c\ub825\uc744 \uc5f0\uc7a5\ud558\ub294 \uac74 \ub2e4\ub974\ub2e4. [\uc6b0\ub9ac\ub294 \uc5ec\ub7ec \uc778\uacf5 \uc7a5\uce58\ub4e4\uacfc \ub204\uc6cc \ub354 \uc624\ub798 \uc0b4\uace0 \uc2f6\uc5b4 \ud558\uc9c0 \uc54a\ub294\ub2e4. \uc6b0\ub9ac\ub294 \ub354 \uc80a\uac8c  \uc0b4\uace0 \uc2f6\uc5b4\ud55c\ub2e4. \uadf8\uac83\ub9cc\uc774 \uac00\uce58\uac00 \uc788\ub2e4.]<\/p>\n\n\n\n

1\ubd80. \uc6b0\ub9ac\uac00 \uc54c\uace0 \uc788\ub294 \uac83\ub4e4
[\uc6d0\uc2dc\uc2dc\ub300\ub85c \uac70\uc2ac\ub7ec \uc62c\ub77c\uac00 \uc6b0\ub9ac\uac00 \ub299\ub294 \uc774\uc720\ub97c \uc124\uba85\ud55c\ub2e4]
.\uc6d0\uc2dc \uc9c0\uad6c\uc5d0 \uc788\ub358 \ubd84\uc790\ub4e4\uc774 \ubaa8\uc5ec \ud575\uc0b0\uc744 \uc774\ub8e8\uace0, \ud575\uc0b0\uc774 \ub18d\ucd95\ub418\ub294 \uacfc\uc815\uc5d0\uc11c \uc911\ud569\uccb4polymer\ub97c \ud615\uc131\ud55c\ub2e4. \uc774\ud6c4 RNA\uac00 \ub418\uace0, DNA\uac00 \ub9cc\ub4e4\uc5b4\uc9c4\ub2e4. \ub9cc\ub4e4\uc5b4\uc9c4 \uc720\uc804 \ubb3c\uc9c8\uc774 \uc9c0\ubc29\uc0b0\uc5d0 \uac10\uc2f8\uc774\uba74\uc11c \ubbf8\uc138\ud55c \ube44\ub217\ubc29\uc6b8\ucc98\ub7fc \ub41c\ub2e4. \uc774\uac83\uc758 \uc138\ud3ec\uc758 \ucd5c\ucd08 \ubaa8\uc2b5\uc774\ub2e4. \uc774 \uc6d0\uc2dc \uc138\ud3ec\ub4e4\uc758 \uc77c\ubd80\ub294 \uc6d0\uc2dc\uc801\uc778 \ub300\uc0ac \uacbd\ub85c\ub97c \uac16\ucd94\uae30 \uc2dc\uc791\ud558\uace0, RNA\uc758 \ubcf5\uc81c\uac00 \uc2dc\uc791\ub41c\ub2e4. \uadf8\ub7ec\ub2e4 \ud55c \uc885, magna superstes(\ub9c8\uadf8\ub098 \uc218\ud398\ub974\uc2a4\ud14c\uc2a4 – \uc704\ub300\ud55c \uc0dd\uc874\uc790, \uc791\uac00\uac00 \ubd99\uc778 \uc784\uc758\uc758 \uc774\ub984\uc784) \uc774 \ub0a8\ub294\ub2e4. \uc774 \uc885\uc740 \uc720\uc804\uc801 \uc0dd\uc874 \uba54\ucee4\ub2c8\uc998\uc744 \uac16\uace0 \uc788\ub2e4. \uc774 \uac04\ub2e8\ud55c \uba54\ucee4\ub2c8\uc998\uc740 \ub450 \uac1c\uc758 \uc720\uc804\uc790\ub85c \uc774\ub8e8\uc5b4\uc9c4\ub2e4.
\uc720\uc804\uc790 A\ub294 \ud658\uacbd\uc774 \uc548 \uc88b\uc744 \ub54c \ubc88\uc2dd\uc744 \uba48\ucd94\uac8c \ud55c\ub2e4. \uadf8\ub807\uac8c \ud568\uc73c\ub85c\uc368 \uc0dd\uc874\ub960\uc744 \ub192\uc778\ub2e4.
\uc720\uc804\uc790 B\ub294 \uce68\ubb35\uc2dc\ud0a4\ub294 siilencing \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4e0\ub2e4. \uc774 \uce68\ubb35 \ub2e8\ubc31\uc9c8\uc740 \uc0c1\ud669\uc774 \uc88b\uc744 \ub54c A\uc5d0 \ub2ec\ub77c\ubd99\uc5b4 \uadf8 \uc720\uc804\uc790\ub97c \ub048\ub2e4. \uadf8\ub7ec\uba74 \ubc88\uc2dd\uc744 \uc7ac\uac1c\ud55c\ub2e4.
\uc774 \ub450 \uac00\uc9c0\uc758 \uc720\uc804\uc790\ub294 \uc6d0\uc2dc \uc9c0\uad6c\uc758 \ubaa8\ub4e0 \uc0dd\ubb3c\ub4e4\uc5d0 \uc788\uc5c8\uc73c\ub098, \ub9c8\uadf8\ub098 \uc218\ud398\ub974\uc2a4\ud14c\uc2a4\uc758 \ub3c5\ud2b9\ud55c \uc810\uc740, \uc720\uc804\uc790 B\uc5d0 \uae30\ub2a5\uc774 \ud558\ub098 \ucd94\uac00\ub418\uc5c8\ub2e4\ub294 \uac83. DNA\uc758 \uc218\uc120\uc744 \ub3d5\ub294\ub2e4. \uc138\ud3ec\uc758 DNA\uac00 \uc190\uc0c1\ub418\uba74 B\uac00 \ub9cc\ub4dc\ub294 \uce68\ubb35 \ub2e8\ubc31\uc9c8\uc774 \uc218\uc120\uc744 \ub3d5\uae30 \uc704\ud574 \uc6d0\ub798 \ubd99\uc5b4 \uc788\ub358 \uc720\uc804\uc790 A\ub97c \ub5a0\ub09c\ub2e4. \uadf8\ub807\uac8c \ud568\uc73c\ub85c\uc368 DNA\uac00 \uc190\uc0c1\ub418\uc5c8\uc73c\uba74 \ubc88\uc2dd\uc744 \uba48\ucd94\uace0, DNA \uc218\uc120\uc774 \uc644\ub8cc \ub418\uba74 \ubc88\uc2dd\uc744 \uc7ac\uac1c\ud55c\ub2e4.
\uc774\ud6c4 \uc6d0\uc2dc \uc9c0\uad6c\uc5d0 \uc6b0\uc8fc\uc120\uc774 \ub0b4\ub9ac\ucb14\ub2e4. \uadf8\ub7fc\uc73c\ub85c\uc368 DNA\uc5d0 \uc190\uc0c1\uc774 \uc77c\uc5b4\ub098\uace0, \uc190\uc0c1\uc744 \ud68c\ubcf5\ud560 \ud68c\ub85c\ub97c \uac16\uace0 \uc788\uc9c0 \uc54a\uc740 \ub2e4\ub978 \uc0dd\uba85\uccb4\ub4e4\uc740 \uc190\uc0c1\ub41c DNA\ub85c \ubcf5\uc81c\ub97c \uc2dc\uc791\ud558\uace0, \ubaa8\ub450 \uc8fd\uc5b4\uc11c \uc0ac\ub77c\uc9c4\ub2e4. \uc774\ud6c4 \uac74\uae30\uac00 \ub05d\ub098\uace0, \ub2e4\uc2dc \ud638\uc218\uc5d0 \ubb3c\uc774 \ucc28\uba74 \ubc88\uc2dd\uc744 \uc7ac\uac1c\ud55c\ub2e4.
\/\/ \uc774\uac83\uc774 \uc2e4\uc874 \uc0dd\ubb3c\uc778\uc9c0\ub294 \uc544\ubb34\ub3c4 \ubaa8\ub974\ub098, \uc800\uc790\uc758 25\ub144 \uc5f0\uad6c\ub294 \uc774\uc640 \ub3d9\uc77c\ud558\uac70\ub098 \ube44\uc2b7\ud55c \uc0dd\ubb3c\uc758 \uc874\uc7ac\ub97c \uc554\uc2dc\ud55c\ub2e4\uace0 \ud568. \uc9c0\uad6c\uc5d0 \uc0ac\ub294 \ubaa8\ub4e0 \uc0dd\ubb3c\uc740 \ub3d9\uc77c\ud55c \ud615\ud0dc\ub85c \uace0\ub300\uc758 \uc774 \uc720\uc804\uc801 \ud68c\ub85c\ub97c \uc5ec\uc804\ud788 \uc9c0\ub2c8\uace0 \uc788\ub2e4. \ubaa8\ub4e0 \uc2dd\ubb3c, \uacf0\ud321\uc774, \ub3d9\ubb3c, \uc778\uac04\uc5d0\uac8c \ub4e4\uc5b4\uc788\ub2e4.
\uc774 \uc0dd\uc874 \ud68c\ub85c\ub294 \uc6b0\ub9ac\uac00 \uc0b4\uc544\ub0a8\uac8c \ud558\ub294 \uae30\uc801\uc744 \ub9cc\ub4e4\uc5b4 \ub0c8\uc73c\ub098, \uc6b0\ub9ac\ub97c \ub299\uac8c \ub9cc\ub4e4\uae30\ub3c4 \ud55c\ub2e4. \ub178\ud654\uc758 \uc6d0\uc778\uc740 \ub2e8 \ud55c\uac00\uc9c0, \uc774\uac83\uc774\ub2e4.<\/p>\n\n\n\n

\ub299\ub294 \uc774\uc720\uc5d0 \ub300\ud55c \uacfc\uac70\uc758 \uace0\ucc30\ub4e4
. \uc0dd\ubb3c\uc774 \uc885\uc744 \uc704\ud574 \ub299\uc5b4 \uc8fd\ub294\ub2e4\uace0 \ub110\ub9ac \ubc1b\uc544\ub4e4\uc5ec\uc84c\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub294 \uc644\uc804\ud788 \ud2c0\ub838\ub2e4. \uac1c\uccb4\ub294 \uc790\uae30 \ubcf4\uc804\uc744 \ucd94\uad6c\ud55c\ub2e4. \uac00\ub2a5\ud55c \ud55c \uc77c\ucc0d, \uac00\ub2a5\ud55c \ud55c \uc624\ub798 \ubc88\uc2dd\uc744 \ud558\ub824\uace0 \uc560\uc4f4\ub2e4.
. \ud1a0\uba38\uc2a4 \ucee4\ud06c\uc6b0\ub4dc -> \uc77c\ud68c\uc6a9 \uccb4\uc138\ud3ec \uac00\uc124\/ \uc790\uc6d0\uc740 \ud55c\uc815\ub418\uc5b4 \uc788\uae30\uc5d0, \ubc88\uc2dd\uacfc \uc0dd\uc874 \uc911 \ud558\ub098\ub97c \uc120\ud0dd\ud574\uc57c \ud55c \ub2e4. \uc77c\ucc0d \ubc88\uc2dd\ud558\uace0 \uc77c\ucc0d \uc8fd\uac70\ub098, \ub2a6\uac8c \ubc88\uc2dd\ud558\uba74\uc11c \ubab8\uc744 \uc720\uc9c0\ud558\uac70\ub098.
  \uc774 \uac00\uc124\uc740 \uc124\ub4dd\ub825 \uc788\ub294 \uc0ac\ub840\ub85c \uc124\uba85\ub41c\ub2e4. \ub2f9\uc2e0\uc774 \uc7a1\uc544\uba39\ud790 \ud655\ub960\uc774 \ub192\uc740 \uc124\uce58\ub958\ub77c\uba74, \uc720\uc804\uc790\ub97c \ube68\ub9ac \ud6c4\ub300\ub85c \uc804\ub2ec\ud560 \ud544\uc694\uac00 \uc788\ub2e4. \ub354 \uc624\ub798 \uc0ac\ub294 \ubab8\uc740 \ub2f9\uc2e0\uc758 \uc885\uc5d0\uc11c \ud37c\uc9c0\uc9c0 \uc54a\uc558\ub2e4. \uc624\ub798 \uc0b4\uba74, \ud2bc\ud2bc\ud558\uc9c0 \ubabb\ud55c \ubab8\uc77c\ud14c\ub2c8 \ud3ec\uc2dd\uc790\ub97c \uc7a5\uae30\uac04 \ud53c\ud560 \uc218 \uc5c6\uc5c8\uc744 \ud14c\ub2c8\uae4c.
\ubc18\ub300\ub85c \ub2f9\uc2e0\uc774 \uba39\uc774\uc0ac\uc2ac\uc758 \uaf2d\ub300\uae30\uc5d0 \uc788\ub294 \ub9f9\uae08\ub958\ub77c\uace0 \ud558\uba74, \ub2f9\uc2e0\uc758 \uc720\uc804\uc790\ub294 \uc218\uc2ed\ub144 \ub3d9\uc548 \ubc88\uc2dd\ud560 \uc218 \uc788\ub294 \ud2bc\ud2bc\ud558\uace0 \uc624\ub798 \uc720\uc9c0\ub41c\ub290 \ubab8\uc744 \ub9cc\ub4e4 \ub54c \ud61c\ud0dd\uc744 \ubcf8\ub2e4. \uadf8 \ub300\uc2e0 \ud55c \ud574\uc5d0 \uc0c8\ub07c\ub97c \ub9ce\uc774 \uae30\ub97c \uc5ec\uc720\ub294 \uc5c6\ub2e4. [ \uc0dd\uc950\ub294 \uaca8\uc6b0 3\ub144\uc744 \uc0ac\ub294\ub370, \uc5b4\ub5a4 \uc0c8\ub4e4\uc740 100\ub144\uae4c\uc9c0 \uc0b0\ub2e4\uace0 \ud568. \uc774 \uc5bc\ub9c8\ub098 \ub180\ub77c\uc6b4 \ud1b5\ucc30\uc778\uac00?]
\uc0dd\ubb3c\uc774 \uc720\uc804\uc790\ub97c \uc131\uacf5\uc801\uc73c\ub85c \uc804\ub2ec\ud558\uba74 \uc790\uc5f0\uc120\ud0dd\uc774 \ubd88\uba78\uc744 \uc120\ud0dd\ud558\uc9c0 \uc54a\ub294\ub2e4. \uc790\uc6d0\uc774 \ud55c\uc815\ub418\uc5b4 \uc788\uae30\uc5d0 \ubc88\uc2dd\uc774\ub098 \uc218\uba85 \uc911 \ud558\ub098\uc5d0 \ud560\ub2f9\ud654\ub85d \uc9c4\ud654\ud588\uae30 \ub54c\ubb38. \ubaa8\ub4e0 \uc885\ub4e4\uc740 \uadf8\ub7ec\ud588\uc73c\ub098, \ud638\ubaa8 \uc0ac\ud53c\uc5d4\uc2a4\ub294 \ucee4\ub2e4\ub780 \ub1cc\uc640 \ubc88\ucc3d\ud558\ub294 \ubb38\uba85\uc744 \ud65c\uc6a9\ud574 \uc9c4\ud654\uc801\uc73c\ub85c \ubd88\ub9ac\ud55c \uc57d\uc810\ub4e4\uc744 \uadf9\ubcf5\ud558\uba74\uc11c \ud601\uc2e0\uc744 \uacc4\uc18d\ud574 \uc654\ub2e4. \uc218\uba85\uc744 \uc810\uc810 \ub298\ub9ac\ub294 \uac83.<\/p>\n\n\n\n

\ub178\ud654 \uc774\ub860\uc758 \uadfc\ubcf8\uc801\uc778 \uc124\uba85
. \ub178\ud654\uc758 \ud1b5\uc77c\ub41c \uc774\ub860\uc774 \ud544\uc694\ud558\ub2e4.
. \ud53c\ud130 B. \uba54\ub354\uc6cc\uc640 \ub808\uc624 \uc2e4\ub77c\ub974\ub4dc\uac00 \uc81c\uc2dc\ud55c \uac00\uc124 : \ub178\ud654\uac00 DNA \uc190\uc0c1\uacfc \uadf8\uc5d0 \ub530\ub978 \uc720\uc804 \uc815\ubcf4\uc758 \uc0c1\uc2e4\ub85c \uc0dd\uae34\ub2e4
.  \ub808\uc2ac\ub9ac \uc624\uac94 : \uc624\ub958 \ud30c\uad6d \uac00\uc124 ERROR CATASTROPHE HYPOTHESIS  DNA \ubcf5\uc81c \uacfc\uc815\uc5d0\uc11c \uc77c\uc5b4\ub09c \uc624\ub958\uac00 \uc720\uc804\uc790\uc5d0 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uc77c\uc73c\ud0a4\uace0, \uadf8\uc5d0 \ub530\ub77c \ubcf5\uc81c \uacfc\uc815\uc774 \uc810\uc810 \uad50\ub780\ub418\uba74\uc11c \ubcf5\uc81c\uac00 \ubd80\uc815\ud655\ud558\uac8c \uc774\ub904\uc9c4\ub2e4.
. \ub370\ub118 \ud558\uba3c -\ub178\ud654\uac00 \uc138\ud3ec \ub0b4\uc758 \uc790\uc720 \ub77c\ub514\uce7c \uc804\uc790 \ub54c\ubb38\uc5d0 \uc77c\uc5b4\ub09c\ub2e4. \uc0b0\ud654\ub97c \uc77c\uc73c\ucf1c\uc11c DNA \ub97c \uc190\uc0c1\uc2dc\ud0a4\uae30 \ub54c\ubb38. [\ud754\ud788 \ud65c\uc131 \uc0b0\uc18c\ub77c\uace0 \ubd80\ub974\ub294 \uac83\ub4e4] 
\/\/ \ud56d\uc0b0\ud654\uc81c\uac00 \uc218\uba85\uc744 \ub298\ub9ac\ub294\uc9c0 \uacc4\uc18d \uc870\uc0ac\ud588\uc73c\ub098, \uc5b4\ub5a4 \ud56d\uc0b0\ud654\uc81c\ub3c4 \ucd5c\ub300 \uc218\uba85\uc744 \ub298\ub9ac\uc9c0 \ubabb\ud588\ub2e4. \ud3c9\uade0\uc218\uba85\uc740 \ub298\uc5c8\uc74c. \uadf8\ub7ec\ub098 \uc544\uc9c1\ub3c4 \ud65c\uc131\uc0b0\uc18c\ub97c \uc5c6\uc560\ub294 “\ud56d\uc0b0\ud654”\ub77c\ub294 \ud0a4\uc6cc\ub4dc\ub294 \ub110\ub9ac \ud314\ub9ac\ub294 \uac74\uac15\uc2dd\ud488 \ud0a4\uc6cc\ub4dc\ub2e4.
. \uc2e4\ub77c\ub974\ub4dc\ub294 \uc778\uac04 \uc138\ud3ec\uc758 \ud074\ub860\uc744 \ub9cc\ub4e4\uc5b4 \ub0c4\uc73c\ub85c\uc368 \uc790\uc2e0\uc758 \uac00\uc124\uc744 \ubc18\uc99d\ud588\ub2e4. \ub299\uc740 \uc138\ud3ec\uac00 \uc911\uc694\ud55c \uc720\uc804 \uc815\ubcf4\ub97c \uc783\uc5b4\ubc84\ub838\ub2e4\uba74, \ub299\uc740 \uac1c\uccb4\ub85c\ubd80\ud130 \ubcf5\uc81c\ub41c \uac1c\uccb4\ub294 \uc5ec\uc804\ud788 \ub299\uc5b4 \uc788\uc5b4\uc57c \ud55c\ub2e4. \ud558\uc9c0\ub9cc \uadf8\ub7ec\uc9c0 \uc54a\uc558\uc74c.
\uace0\ub85c, \ub178\ud654\ub294 \uc0b0\ud654\ub85c \uc778\ud55c DNA(\ud2b9\ud788 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 DNA)\uc758 \uc190\uc0c1 \ub54c\ubb38\ub3c4 \uc544\ub2c8\uace0, \uc138\ud3ec\ud575 DNA\uc758 \ub3cc\uc5f0\ubcc0\uc774 \ub54c\ubb38\ub3c4 \uc544\ub2c8\ub2e4.<\/p>\n\n\n\n

.\uacfc\ud559\uc801 \ud569\uc758 : \ub178\ud654\uc640 \uc218\ubc18\ub418\ub294 \uc9c8\ubcd1\uc740 \ub178\ud654\uc758 \uc5ec\ub7ec \uc9d5\ud45c\ub4e4\uc758 \uc0b0\ubb3c\uc774\ub2e4.
\uc9d5\ud45c\ub4e4 : 1. DNA \uc190\uc0c1\uc73c\ub85c \uc778\ud55c \uc720\uc804\uc801 \ubd88\uc548\uc815
2. \ud154\ub85c\ubbf8\uc5b4\uc758 \ub9c8\ubaa8
3. \uc5b4\ub290 \uc720\uc804\uc790\uac00 \ucf1c\uc9c0\uace0 \uaebc\uc9c8\uc9c0\ub97c \uc870\uc808\ud558\ub294 \ud6c4\uc131\uc720\uc804\uccb4epigenome\uc758 \ubcc0\ud654[ \uc720\uc804\uc790 B\uaca0\uc8e0?]
4. \ub2e8\ubc31\uc9c8\uc744 \uac74\uac15\ud558\uac8c \uc720\uc9c0\ud558\ub294 \ub2a5\ub825(\ub2e8\ubc31\uc9c8 \ud56d\uc0c1\uc131 proteostasis)\uc758 \uc0c1\uc2e4
5. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5 \uc774\uc0c1
6. \ub300\uc0ac \ubcc0\ud654\ub85c \uc0dd\uae30\ub294 \uc601\uc591\uc18c \uac10\uc9c0 \ub2a5\ub825\uc758 \ud63c\ub780
7. \uac74\uac15\ud55c \uc138\ud3ec\uc5d0 \uc5fc\uc99d\uc744 \uc77c\uc73c\ud0a4\ub294 \ub178\ud654 \uc138\ud3ec\uc758 \ucd95\uc801
8. \uc904\uae30\uc138\ud3ec\uc758 \uc18c\uc9c4
9. \uc138\ud3ec \ub0b4 \uc758\uc0ac\uc18c\ud1b5\uc758 \ubcc0\ud615\uacfc \uc5fc\uc99d \ubd84\uc790\uc758 \uc0dd\uc131
\uc9c0\ub09c \uba87 \uc2ed\ub144 \uac04, \uacfc\ud559\uc790\ub4e4\uc740 \uc774 \uac01\uac01\uc758 \uc9d5\ud45c\ub4e4\uc5d0 \ub300\uc751\ud558\ub294 \uac8c \ub178\ud654\ub97c \ub9c9\ub294 \ucd5c\uc120\uc774\ub77c\uace0 \uc0dd\uac01\ud588\ub2e4. \uc774\ub7f0 \uc9d5\ud45c\ub4e4\uacfc \uc99d\uc0c1\ub4e4\uc774 \ub178\ud654\uc758 \uc9c0\ud45c\uc784\uc744 \ud655\uc2e0\ud558\uace0 \uc788\uc73c\ub098, \uc544\uc9c1 \uc6b0\ub9ac\ub294 \uc774\ub7f0 \uc9d5\ud45c\ub4e4\uc774 \uc65c \uc0dd\uaca8\ub098\ub294\uc9c0\ub294 \uc124\uba85\ud560 \uc218\uac00 \uc5c6\ub2e4.<\/p>\n\n\n\n

“\uc6b0\ub9ac\ub294 \uc65c \ub299\ub294\uac00?”\uc5d0 \ub300\ud55c \ub2e8\uc77c\ud55c \ub300\ub2f5 – \ub178\ud654\uc758 \uc815\ubcf4 \uc774\ub860
<\ub178\ud654\ub294 \uc815\ubcf4\uc758 \uc0c1\uc2e4\uc774\ub2e4> \/\uc2e4\ub77c\ub974\ub4dc\uc640 \uba54\ub354\uc6cc\uc758 \uac1c\ub150\uacfc\ub294 \ub2e4\ub974\ub2e4. \uadf8\ub4e4\uc740 ‘\uc720\uc804 \uc815\ubcf4\uc758 \uc0c1\uc2e4’\uc5d0 \ucd08\uc810\uc744 \ub9de\ucdc4\ub2e4. \uadf8\ub7ec\ub098 \uc720\uc804 \uc815\ubcf4\ub294 \uc0c1\uc2e4\ub418\uc9c0 \uc54a\ub294\ub2e4.
\uc0dd\ubb3c\uc5d0\uac8c\ub294 \ub450 \uc885\ub958\uc758 \uc815\ubcf4\uac00 \uc788\ub2e4. \uccab \uc720\ud615\uc758 \uc815\ubcf4\ub294 \ub514\uc9c0\ud138, \uc989 A, G, T,C\ub85c \uc774\ub904\uc9c4 \uc0ac\uc9c4\uc218 \ucf54\ub4dc\ub97c \uc4f4\ub2e4. \ub514\uc9c0\ud138 \uc815\ubcf4\ub294 \uc815\ubcf4\uc758 \uc800\uc7a5\uacfc \ubcf5\uc81c\ub97c \uc2e0\ub8b0\ud560 \uc218 \uc788\ub2e4. (\ub9c8\uce58 \ucef4\ud4e8\ud130 \ud558\ub4dc\ub514\uc2a4\ud06c \uac19\uc740 \uac83\ucc98\ub7fc) \ub610\ud55c, \ud2bc\ud2bc\ud558\ub2e4. \ub053\ub294 \ubb3c\uc5d0\uc11c \uba87 \uc2dc\uac04 \ub3d9\uc548 \uacac\ub51c \uc218 \uc788\uc73c\uba70, 4\ub9cc\ub144 \ub41c \uc778\ub958\uc758 \ubf08\uc5d0\uc11c \ucd94\ucd9c\ud560 \uc218\ub3c4 \uc788\ub2e4. \uc720\uc804 \uc815\ubcf4\ub294 DNA\uc5d0 \ub514\uc9c0\ud138 \ubc29\uc2dd\uc73c\ub85c \uc800\uc7a5\ub41c\ub2e4.
\ub450 \ubc88\uc9f8 \uc720\ud615\uc758 \uc815\ubcf4\ub294 \uc544\ub0a0\ub85c\uadf8 \ud615\ud0dc\ub2e4. \uc624\ub298\ub0a0 \ud754\ud788 \ud6c4\uc131\uc720\uc804\uccb4epigenome\ub77c\uace0 \ubd88\ub9b0\ub2e4. \uc720\uc804\uc801 \uc218\ub2e8\uc744 \ud1b5\ud574 \uc804\ub2ec\ub418\uc9c0 \uc54a\ub294 \uc720\uc804 \uac00\ub2a5\ud55c \ud615\uc9c8(..? \ubb54\uc18c\ub9ac\uc57c) \ud6c4\uc131\uc720\uc804 \uc815\ubcf4\ub294 \uc5fc\uc0c9\uc9c8(DNA\uc640 \ud788\uc2a4\ud1a4 \ub2e8\ubc31\uc9c8\ub85c \uad6c\uc131\ub41c \ubcf5\ud569\uccb4)\uc5d0 \uc800\uc7a5\ub41c\ub2e4. \uc774 \ud6c4\uc131\uc720\uc804 \uc815\ubcf4\uc758 \uc800\uc7a5\uacfc \uc804\ub2ec\uc740 \uc0dd\uc874\uc5d0 \ud544\uc218\uc801\uc774\ub2e4. \uc774 \ud6c4\uc131 \uc720\uc804 \uc815\ubcf4\ub294 \ud558\ub098\uc758 \uc218\uc815\ub780\uc5d0\uc11c 260\uc5b5 \uac1c\uc758 \uc138\ud3ec\ub85c \uc774\ub904\uc9c4 \uc2e0\uc0dd\uc544\uac00 \ub418\uae30\uae4c\uc9c0\uc758 \ubc1c\uc0dd \uacfc\uc815\uc744 \uc870\uc728\ud558\uace0, \uc720\uc804\uc801\uc73c\ub85c \ub3d9\uc77c\ud55c \uc138\ud3ec\ub4e4\uc774 \uc6b0\ub9ac \ubab8\uc5d0\uc11c \uc218\ucc9c\uac00\uc9c0 \uc138\ud3ec\ub85c \ubd84\ud654\ud560 \uc218 \uc788\ub3c4\ub85d \ud55c\ub2e4.
\ud6c4\uc131\uc720\uc804 \uc815\ubcf4\ub294 \uc18c\ud504\ud2b8\uc6e8\uc5b4\ub77c\uace0 \ubcf4\uba74 \ub41c\ub2e4. \ubd84\uc5f4\ub41c \uc138\ud3ec\uac00 \uc5b4\ub5a4 \uc885\ub958\uc758 \uc138\ud3ec\ub85c \ubc1c\ub2ec\ud560\uc9c0 \uc9c0\uc2dc\ud558\uace0, \ud55c \uc885\ub958\uc758 \uc138\ud3ec\uac00 \uc218\uc2ed \ub144 \ub3d9\uc548 \uc815\uccb4\uc131\uc744 \uc720\uc9c0\ud558\ub3c4\ub85d \ud574 \uc900\ub2e4. (\uc608\uc2dc : \ub274\ub7f0\uc774 \uac11\uc790\uae30 \ud53c\ubd80\uc138\ud3ec\ucc98\ub7fc \ud589\ub3d9\ud558\uc9c0 \uc54a\uace0, \ubd84\uc5f4\ud558\ub294 \ucf69\ud325 \uc138\ud3ec\uac00 \uac11\uc790\uae30 \uc2ec\uc7a5\uc138\ud3ec\uac00 \ub418\uc9c0 \uc54a\ub294 \uc774\uc720.)
\uc6d0\uc2dc\uc9c0\uad6c\uc5d0\uc11c \ub514\uc9c0\ud138 \ubc29\uc2dd\uc740 \uc720\uc804 \uc815\ubcf4\ub97c \uc7a5\uae30\uac04 \uc800\uc7a5\ud558\ub294 \ucd5c\uace0\uc758 \ubc29\ubc95\uc774\uc5c8\ub2e4. \uadf8\ub7ec\ub098 \ud658\uacbd \uc870\uac74\uc744 \uae30\ub85d\ud558\uace0 \uac70\uae30\uc5d0 \ubc18\uc751\ud558\ub294 \ub370 \ud544\uc694\ud55c \uc815\ubcf4\ub294 \uc544\ub0a0\ub85c\uadf8 \ubc29\uc2dd\uc73c\ub85c \uc800\uc7a5\ud558\ub294 \uac8c \ucd5c\uc120\uc774\uc5c8\ub2e4. \uc27d\uac8c \uaebc\ub0b4\uace0 \uc800\uc7a5\ud558\uace0 \uc218\uc815\ud560 \uc218 \uc788\uae30\uc5d0 \ubb34\ud55c\ud55c \uac00\ub2a5\uc131\uc744 \uac00\uc9c0\uae30 \ub54c\ubb38.
\uadf8\ub7ec\ub098 \uc774\ub807\uac8c \uc544\ub0a0\ub85c\uadf8 \ud615\uc2dd\uc73c\ub85c \uc800\uc7a5\ud55c \uc815\ubcf4\ub294 \uc2dc\uac04\uc774 \ud750\ub974\uba74\uc11c \ubcc0\uc9c8\ub41c\ub2e4. \uc790\uae30\uc7a5, \uc911\ub825, \uc6b0\uc8fc\uc120, \uc0b0\uc18c \ub4f1\uc5d0 \uc758\ud574. \uac8c\ub2e4\uac00 \ubcf5\uc81c\ud558\uba74\uc11c \uc77c\ubd80\ub97c \uc783\ub294\ub2e4.
\uc6b0\ub9ac\ub294 \uae68\uc9c4 DVD\ub85c\ubd80\ud130 \uc815\ubcf4\ub97c \ubcf5\uc6d0\ud560 \uc218\ub294 \uc5c6\uc73c\ub098, \uae01\ud78c DVD\ub294 \uc815\ubcf4\ub97c \ubcf5\uc6d0\ud560 \uc218 \uc788\ub2e4. \uc791\uac00\ub294 \ub178\ud654 \uc5ed\uc2dc \uac00\ub2a5\ud558\ub2e4\uace0 \uc0dd\uac01\ud55c\ub2e4. \ubcf5\uc81c \uc0dd\ubb3c\uc774 \uc99d\uba85\ud588\ub4ef\uc774, \uc6b0\ub9ac\uac00 \ub299\uc5b4\ub3c4 \uc0dd\ubb3c\uc740 \uc5ec\uc804\ud788 \uc80a\uc744 \ub54c\uc758 \ub514\uc9c0\ud138 \uc815\ubcf4\ub97c \uac16\uace0 \uc788\ub2e4. \ub2e4\uc2dc \uc80a\uc5b4 \uc9c0\ub824\uba74 \uadf8 \uc815\ubcf4\ub97c \ucc3e\uae30\ub9cc \ud558\uba74 \ub41c\ub2e4.
[\uc774 \ucc45\uc5d0\uc11c \uc774 \ub0b4\uc6a9\uc774 \uac00\uc7a5 \uc8fc\ub41c \ub0b4\uc6a9\uc774\ub2e4. \uac00\uc7a5 \ud601\uc2e0\uc801\uc778 \ub0b4\uc6a9\uc774\uae30\ub3c4 \ud558\ub2e4. \ub0b4\uac00 \uc0c1\uc0c1\ub3c4 \ubabb\ud55c \ubc29\uc2dd\uc73c\ub85c \ub178\ud654\ub97c \uc815\uc758\ud558\uace0, \ub610\ud55c \uadf8 \uadfc\uac70 \uc5ed\uc2dc \ud0c4\ud0c4\ud558\ub2e4. \ubaa8\ub4e0 \ucc45\uc758 \ub0b4\uc6a9\uc740 \uc5ec\uae30\uc11c \uc2dc\uc791\ud55c\ub2e4. ]<\/p>\n\n\n\n

\uc6d0\uc2dc\uc801\uc778 \uc0dd\uc874 \ud68c\ub85c(\uc720\uc804\uc790 A\uc640 \uc720\uc804\uc790 B)\ub294 \uc2dc\uac04\uc774 \ud750\ub974\uba74\uc11c \uc544\uc8fc \ubcf5\uc7a1\ud574\uc84c\uace0, \uc6b0\ub9ac\ub294 22\uac1c \uc774\uc0c1\uc758 \uadf8\ub7f0 \uc720\uc804\uc790\ub97c \uac16\uace0 \uc788\ub2e4. \uc774\ub7ec\ud55c \uc720\uc804\uc790\ub294 \uc0b6\uc744 \ub298\ub9ac\uace0, \ub354 \uac74\uac15\ud558\uac8c \ub9cc\ub4e0\ub2e4. \uc774 \uc720\uc804\uc790\ub4e4\uc740 \ubab8\uc744 \uad6c\uc131\ud558\ub294 \uc138\ud3ec\ub4e4\uacfc \uae30\uad00\ub4e4\uc774 \uc758\uc0ac\uc18c\ud1b5\uc744 \ud558\uac8c \ud558\ub294 \uc77c\uc885\uc758 \uac10\uc2dc\ub9dd\uc744 \ud615\uc131\ud55c\ub2e4. \uc0c1\ud669\uc774 \uc548 \uc88b\uc73c\uba74 \uc7a0\uc2dc \uc228\uc8fd\uc774\uace0 \uc788\uc73c\ub77c\uace0 \ud558\uace0, \uc0c1\ud669\uc774 \ub098\uc544\uc9c0\uba74 \ube68\ub9ac \uc131\uc7a5\ud574 \ubc88\uc2dd\ud558\ub77c\uace0 \ub9d0\ud55c\ub2e4.
\uc7a5\uc218 \uc720\uc804\uc790\ub294 sirtuin(\uc11c\ud22c\uc778)\uc774\ub77c\ub294 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4e0\ub2e4.\ud6a8\ubaa8\uc5d0\uc11c sir2 \uc720\uc804\uc790\uac00 \ucc98\uc74c \ubc1c\uacac\ub418\uc5c8\ub2e4. \ud3ec\uc720\ub958\ub294 sirt1 \uc5d0\uc11c sirt7\uae4c\uc9c0 \uc788\ub2e4. \uc774\ub294 \ubaa8\ub4e0 \uc138\ud3ec\uc5d0\uc11c \ub9cc\ub4e4\uc5b4\uc9c4\ub2e4. \uc11c\ud22c\uc778\uc740 \uc6d0\uc2dc \uc0dd\uc874\ud68c\ub85c\uc758 \uc720\uc804\uc790 B\uc758 \ud6c4\uc190\uc73c\ub85c\uc368, \ub2e8\ubc31\uc9c8\uc5d0\uc11c \uc544\uc138\ud2f8\uae30 \uaf2c\ub9ac\ud45c\ub97c \uc81c\uac70\ud55c\ub2e4. \uadf8\ub7fc\uc73c\ub85c\uc368 \ud544\uc694\ud560 \ub54c \uc5b4\ub5a4 \uc720\uc804\uc790\ub97c \ucf1c\uac70\ub098 \ub048\ub2e4. \uc774 \ub2e8\ubc31\uc9c8\uc740 \uc138\ud3ec \uc81c\uc5b4 \uc2dc\uc2a4\ud15c\uc758 \ucd5c\uc0c1\uc704\uc5d0 \uc704\uce58\ud558\uace0, \ubc88\uc2dd\uacfc DNA\uc218\uc120\uc744 \uc81c\uc5b4\ud55c\ub2e4. \uc774\ub4e4\uc740 NAD : nicotinamide adenine dinucleotide\ub77c\ub294 \ubd84\uc790\ub97c \uc774\uc6a9\ud55c\ub2e4. \ub098\uc774\ub97c \uba39\uc744\uc218\ub85d NAD\ub294 \uc904\uc5b4\ub4e4\uace0, \uadf8\ub85c \uc778\ud574 \uc11c\ud22c\uc778 \ub2e8\ubc31\uc9c8\uc758 \ud65c\uc131\uc774 \uac10\uc18c\ub41c\ub2e4. \uc774\uac83\uc774 \ubc14\ub85c \ub178\ud654\uc758 \uc6d0\uc778\uc774\ub77c\uace0 \uc5ec\uaca8\uc9c4\ub2e4.
\uc11c\ud22c\uc778\uc740 \uc2a4\ud2b8\ub808\uc2a4\ub97c \ubc1b\uc744 \ub54c \ubc88\uc2dd \ub300\uc2e0 \uc218\uc120\uc5d0 \uc9d1\uc911\ud558\uae30 \uc704\ud574 “\ud5c8\ub9ac\ub760\ub97c \uc870\uc774\uace0” \ub178\ud654\uc758 \uc8fc\uc694 \uc9c8\ubcd1\ub4e4\uacfc, \uc5ec\ub7ec \uc5fc\uc99d\ubc18\uc751\uc5d0 \ub9de\uc120\ub2e4. \uae30\ud0c0 \ub4f1\ub4f1 \uc548 \uc88b\uc740 \uac83\ub4e4\uc5d0 \ub300\ud56d\ud55c\ub2e4.
\\  \ube44\uc2b7\ud55c \ub2e8\ubc31\uc9c8\ub85c TOR target of rapamycin\uc774\ub77c\ub294 \ub2e8\ubc31\uc9c8\uc774 \uc788\uc74c. \uc11c\ud22c\uc778\uc740 \uc5ec\ub7ec \uc7a5\uc218 \uc720\uc804\uc790 \uc911 \uc791\ub3d9\uc774 \uac04\ub2e8\ud558\uace0, \uc870\uc791\ud560 \uc218 \uc788\uc74c. mTOR(\ud3ec\uc720\ub958\uc758 TOR)\uc740 \ubaa8\ub4e0 \uc0c1\ud669\uc774 \uc88b\uc744 \ub54c, \uac00\uc6a9 \uc544\ubbf8\ub178\uc0b0\uc758 \uc591\uc744 \uac10\uc9c0\ud558\uace0 \uadf8\uc5d0 \ubc18\uc751\ud574 \ub2e8\ubc31\uc9c8\uc744 \uc5bc\ub9c8\ub098 \ub9cc\ub4e4\uc9c0 \uc9c0\uc815\ud55c\ub2e4. \uadf8\ub7ec\ub098 \uc0c1\ud669\uc774 \uc548 \uc88b\uc73c\uba74 \ubd84\uc5f4\uc744 \uba48\ucd94\uace0 \uae30\uc874\uc758 \uc138\ud3ec \uc131\ubd84\ub4e4\uc744 \uc7ac\ud65c\uc6a9\ud574 \uc0dd\uc874\uc744 \ub3c4\ubaa8\ud55c\ub2e4.
\ube44\uc2b7\ud55c \ub2e8\ubc31\uc9c8\ub85c AMPK\uac00 \uc788\ub2e4. AMP-activated protein kinase\/ \uc5d0\ub108\uc9c0\uac00 \uc801\uc744 \ub54c \ubc18\uc751\ud55c\ub2e4.
\uc774\ub7ec\ud55c \ubc29\uc5b4 \uccb4\uacc4\ub4e4\uc740 \ubaa8\ub450 \uc0dd\ubb3c\ud559\uc801 \uc2a4\ud2b8\ub808\uc2a4\uc5d0 \ubc18\uc751\ud574 \ud65c\uc131\ud654\ub41c\ub2e4. \uc5b4\ub5a4 \uc2a4\ud2b8\ub808\uc2a4\ub294 \uadf9\ubcf5\ud558\uae30 \ud798\ub4e4\ub2e4. \uae09\uc131 \uc678\uc0c1\uc774\ub098 \ud1b5\uc81c \ubd88\ub2a5\uc758 \uac10\uc5fc\uc740 \ub178\ud654\uc640 \ubb34\uad00\ud558\uac8c \uc0dd\ubb3c\uc744 \uc8fd\uc778\ub2e4. DNA\uc758 \uc5ec\ub7ec \ubd80\uc704\uac00 \ub04a\uae30\ub294 \uac83\ucc98\ub7fc \uc138\ud3ec \ub0b4\ubd80\uc5d0 \uadf9\uc2ec\ud55c \uc2a4\ud2b8\ub808\uc2a4 \uc0c1\ud669\uc774 \ubc1c\uc0dd\ud558\uba74 \ubcf5\uad6c\ud558\uae30 \uc5b4\ub835\ub2e4. \uc774\ub85c \uc778\ud574 \ud544\uc5f0\uc801\uc73c\ub85c \ud6c4\uc131\uc720\uc804 \uc218\uc900\uc5d0\uc11c\ub294 \uc815\ubcf4 \uc0c1\uc2e4\uc774 \uc77c\uc5b4\ub09c\ub2e4.
\uc138\ud3ec\ub97c \uc190\uc0c1\uc2dc\ud0a4\uc9c0 \uc54a\uc73c\uba74\uc11c \uc7a5\uc218 \uc720\uc804\uc790\ub97c \ud65c\uc131\ud654\ud558\ub294 \ubc29\ubc95(hormesis\/\uc57d\ud55c \uc2a4\ud2b8\ub808\uc2a4\uc5d0 \ubc18\uc751\ud574 \ud65c\uc131\uc744 \ub744\ub294 \ud604\uc0c1) : \uace0\uc628\uacfc \uc800\uc628 \ub178\ucd9c, \uac04\ud5d0\uc801 \ub2e8\uc2dd, \uc800\ub2e8\ubc31\uc9c8 \uc2dd\ub2e8, \uc6b4\ub3d9.<\/p>\n\n\n\n

“\ub178\ud654 \uc720\uc804\uc790”\ub294 \uc5c6\ub2e4!
\uc554\uc744 \uce58\ub8cc\ud558\uae30 \uc704\ud55c \uc8fc\uc694 \ud45c\uc801\uc774 \ub418\ub294 “\uc885\uc591 \uc720\uc804\uc790”\uc640\ub294 \ub2ec\ub9ac, \ub178\ud654\ub97c \uc77c\uc73c\ud0a4\ub294 \uc720\uc804\uc790\ub294 \uc5c6\ub2e4. \uc6b0\ub9ac \uc720\uc804\uc790\ub294 \ub178\ud654\ub97c \uc77c\uc73c\ud0a4\ub3c4\ub85d \uc9c4\ud654\ud558\uc9c0 \uc54a\uc558\uae30 \ub54c\ubb38\uc774\ub2e4.
\uc774\ud6c4 \ud6a8\ubaa8\uc5d0 \ub300\ud55c \uc774\uc57c\uae30, \uc790\uae30\uc758 \uc5f0\uad6c \uc774\uc57c\uae30 \ub4f1 \ud765\ubbf8\ub86d\uace0 \ucc45\uc744 \uacc4\uc18d \uc77d\uac8c \ub9cc\ub4dc\ub294 \ub0b4\uc6a9\uc774 \ub4f1\uc7a5\ud55c\ub2e4. \ud6a8\ubaa8\ub85c \ub178\ud654\uc758 \ube44\ubc00\uc744 \ud30c\ud5e4\uce58\ub824\ub294 \uc791\uac00\uc758 \uc774\uc57c\uae30\ub2e4.
\ud6c4\uc131\uc720\uc804\uccb4\ub294 \ud788\uc2a4\ud1a4\ub2e8\ubc31\uc9c8\uc744 DNA\uac00 \uac10\uc2f8\uace0 \uc788\ub294 \ud615\ud0dc\ub2e4. \uc774 \uac00\ub2e5\uc774 \uac10\uaca8\uc11c \uc5fc\uc0c9\uc9c8\uc744, \uc5fc\uc0c9\uc9c8\uc774 \uac10\uaca8\uc11c \uc5fc\uc0c9\uccb4\ub97c \uc774\ub8ec\ub2e4. \uc11c\ud22c\uc778\uc740 \ud788\uc2a4\ud1a4\uc5d0\uac8c DNA\uc640 \uaf49 \uacb0\ud569\ud558\ub77c\uace0 \uc9c0\uc2dc\ud55c\ub2e4. \ub610\ud55c \uc6d0\ub798 \uc790\ub9ac\ub97c \ub5a0\ub098 \ub3cc\uc544\ub2e4\ub2c8\uae30\ub3c4 \ud55c\ub2e4. \uc774\ub807\uac8c \ud568\uc73c\ub85c\uc368 \uc720\uc804\uc790\ub97c \ucf1c\uace0 \ub048\ub2e4. \uc5b4\ub5a4 \uc720\uc804\uc790\uc5d0 DNA\uacb0\ud569 \uc804\uc0ac \uc778\uc790DNA-binding transcription factor\uac00 \ub2ec\ub77c\ubd99\uc73c\uba74 \ucf1c\uc9c4\ub2e4. \uc804\uc0ac \uc778\uc790\uac00 \ub2ec\ub77c\ubd99\uc744 \uc218 \uc788\ub294 \ubd80\uc704\ub294 \uc9c4\uc815\uc5fc\uc0c9\uc9c8 euchromatin, \ubabb \ub2ec\ub77c\ubd99\ub294(silencing) \ubd80\uc704\ub294 \uc774\uc9c8\uc5fc\uc0c9\uc9c8 heterochromatin\uc774\ub2e4. \uc11c\ud22c\uc778\uc740 \ud788\uc2a4\ud1a4\uc5d0 \ubd99\uc740 \ud654\ud559\uc801 \uaf2c\ub9ac\ud45c(\uc544\uc138\ud2f8\uae30)\ub97c \uc81c\uac70\ud568\uc73c\ub85c\uc368 \uc804\uc0ac \uc778\uc790\uac00 \uc720\uc804\uc790\uc5d0 \ub2ec\ub77c\ubd99\uc9c0 \ubabb\ud558\uac8c \ub9c9\uc74c\uc73c\ub85c\uc368 \uc720\uc804\uc790\ub97c \ub048\ub2e4.
\ub3d9\uc77c\ud55c DNA\ub97c \uac16\uace0 \uc788\ub294 \uc6b0\ub9ac\uc758 \uc138\ud3ec\uac00, \uac01\uae30 \ub2e4\ub978 \uae30\uad00\uc5d0\uc11c \ub2e4\ub978 \uc5ed\ud560\uc744 \ud560 \uc218 \uc788\uac8c  \ubd84\ud654\ud558\ub3c4\ub85d \uc870\uc728\ud558\ub294 \uac8c \uc774 \ud6c4\uc131\uc720\uc804\uccb4\ub2e4. (\uc791\uac00\ub294 \uc774\ub97c \ud53c\uc544\ub178 \uc5f0\uc8fc\uc5d0 \ube44\uc720\ud588\ub2e4. \uc218 \ub9ce\uc740 \uac74\ubc18\uc758 \uc870\ud569\uc73c\ub85c \uc74c\uc545\uc744 \ub9cc\ub4e4\uc5b4\ub0b4\ub294) \uc5f0\uc8fc\uc790(\ud6c4\uc131\uc720\uc804\uccb4)\uac00 \uc5f0\uc8fc\ub97c \ud558\ub2e4\uac00 \uac74\ubc18 \ud558\ub098\ub97c \uc798\ubabb \ub204\ub978\ub2e4. \uc544\ubb34\ub3c4 \uc54c\uc544\ucc28\ub9ac\uc9c0 \ubabb\ud55c\ub2e4. \uadf8\ub7ec\ub098 \uc810\uc810 \ube48\ub3c4\uac00 \ub294\ub2e4. \ud53c\uc544\ub178\uc5d0\ub294 \uc544\ubb34\ub7f0 \ubb38\uc81c\uac00 \uc5c6\uace0, \ud53c\uc544\ub2c8\uc2a4\ud2b8\ub294 \uc791\uace1\uac00\uac00 \uc9c0\uc815\ud55c \uc74c\uc744 ‘\uac70\uc758 \ub2e4’ \uc5f0\uc8fc\ud558\uace0 \uc788\uc73c\ub098, \uc77c\ubd80 \uc74c\uc744 \ucd94\uac00\ub85c \uc5f0\uc8fc\ud558\uace0 \uc788\ub2e4. \uc2dc\uac04\uc774 \ud750\ub974\uba74\uc11c \uc5f0\uc8fc\ud68c\ub294 \uc5c9\ub9dd\uc774 \ub418\uae30 \uc2dc\uc791\ud55c\ub2e4.
\uc774\uac8c \ubc14\ub85c \ub178\ud654\ub2e4. \ud53c\uc544\ub178\ub294 DNA,\uba40\uca61\ud558\ub2e4. \ud6c4\uc131\uc720\uc804\uccb4\uac00 \uc720\uc804\uc790\ub97c \ucf1c\uace0 \ub044\ub294 \uacfc\uc815\uc5d0\uc11c \ubb54\uac00 \uc7a1\uc74c\uc774 \ubc1c\uc0dd\ud558\uace0 ,\uc774\ub7f0 \ud63c\ub780\uc740 \ub300\ubd80\ubd84 DNA\uac00 \ub04a\uae30\ub294 \uc77c\ucc98\ub7fc \uc138\ud3ec\uc5d0 \uc2ec\ud55c \uc190\uc0c1\uc774 \uc77c\uc5b4\ub0a8\uc73c\ub85c\uc368 \uc0dd\uae34\ub2e4. \uc774\ub7ec\ud55c \uc7a1\uc74c\uc774 \uc6b0\ub9ac\uac00 \ub299\ub294 \uc774\uc720\ub2e4.
\ub178\ud654\uc758 \ubcf4\ud3b8\uc801\uc778 \ubaa8\ud615\uc740 \ub2e4\uc74c\uacfc \uac19\ub2e4 : \uc80a\uc74c – DNA\ub04a\uae40 – \uc720\uc804\uccb4 \ubd88\uc548\uc815- DNA \ud3ec\uc7a5\uacfc \uc720\uc804\uc790 \uc870\uc808\uc758 \uad50\ub780 – \uc138\ud3ec \uc815\uccb4\uc131 \uc0c1\uc2e4- \uc138\ud3ec \ub178\ud654 – \uc9c8\ubcd1- \uc8fd\uc74c
\uc6b0\ub9ac\uc758 DNA\ub294 \ub04a\uc784\uc5c6\uc774 \ub04a\uae34\ub2e4. \uc138\ud3ec\uac00 \ubcf5\uc81c\ud560 \ub54c\ub9c8\ub2e4 \uc5b4\ub5a4 \uc2dd\uc73c\ub85c\ub4e0 \ub04a\uae30\uba70, \uc790\uc5f0 \ubc29\uc0ac\uc120, \ud658\uacbd\uc758 \ud654\ud559 \ubb3c\uc9c8, \ubcd1\uc6d0\uc758 \uc5d1\uc2a4\uc120 \ucd2c\uc601\uc5d0\ub3c4\ub04a\uae34\ub2e4. DNA\uac00 \ub04a\uae30\uba74 \uc11c\ud22c\uc778\uc774 DNA\uc218\uc120\uc758 \uc5ed\ud560\uc744 \ud558\uae30 \uc704\ud574 \ub5a0\ub098\uc11c \ub2e4\ub978 \uc5c5\ubb34(DNA \uc548\uc815, \uc138\ud3ec \uc0dd\uc874, \ub300\uc0ac, \uc138\ud3ec \uac04 \uc758\uc0ac\uc18c\ud1b5 \ub4f1)\ub97c \ud558\uc9c0 \ubabb\ud55c\ub2e4. DNA\uac00 \uc790\uc8fc \ub04a\uae38\uc218\ub85d, DNA \uc218\uc120\uc5d0 \uc9d1\uc911\ud574\uc57c \ud558\uae30\uc5d0 \ubcf8\uc5f0\uc758 \ud6c4\uc131\uc720\uc804\uc801 \uae30\ub2a5\uc740 \uc624\ub798 \uc911\ub2e8\ud560 \uc218 \ubc16\uc5d0 \uc5c6\ub2e4.  \ubb38\uc81c\ub294 \uc11c\ud22c\uc778 \ub2e8\ubc31\uc9c8\uc774 \uc6d0\ub798 \uc788\ub358 \uacf3\uc73c\ub85c \ub3cc\uc544\uac00\uc9c0 \uc54a\uc73c\uba74\uc11c \uc77c\uc5b4\ub09c\ub2e4. \uc11c\ud22c\uc778 \ub2e8\ubc31\uc9c8\uc774 \uc6d0\ub798\uc758 \uc720\uc804\uc790\ub97c \ub5a0\ub098\uba74\uc11c \ucf1c\uc84c\ub358 \uc720\uc804\uc790\ub294 \uaebc\uc9c0\uace0 \uaebc\uc84c\ub358 \uc720\uc804\uc790\ub294 \ucf1c\uc9c4\ub2e4. \uadf8\ub9ac\uace0 \ub2e4\uc2dc \uacb0\ud569\ud560 \ub54c\ub294 \ubc18\ub300\uc758 \ud604\uc0c1\uc774 \uc77c\uc5b4\ub09c\ub2e4. \uadf8\ub7ec\uba74\uc11c \uc6b0\ub9ac\uac00 \uc758\ub3c4\ud558\uc9c0 \uc54a\uc558\ub358 \ubc29\uc2dd\uc73c\ub85c \uc720\uc804\uccb4\ub97c \ubc14\uafbc\ub2e4. \uc774\uac83\uc774 \ud6c4\uc131\uc720\uc804\uc801 \uc7a1\uc74c\uc774\ub2e4.
\uc0dd\uc874\ud68c\ub85c\uac00 \uc791\ub3d9\ud558\uace0 \ub178\ud654\uac00 \uc77c\uc5b4\ub098\ub824\uba74 \uc11c\ud22c\uc778 \ub2e8\ubc31\uc9c8\uacfc \uac19\uc740 \ud6c4\uc131\uc720\uc804\uc801 \uc870\uc808 \uc778\uc790\ub4e4\uc774 \ud55c\uc815\ub41c \uc591\uc73c\ub85c \uc874\uc7ac\ud574\uc57c \ud55c\ub2e4. \uadf8\ub798\uc11c \ub04a\uae34 \uc720\uc804\uc790\ub97c \uc218\uc120\ud558\uba74\uc11c \ub3d9\uc2dc\uc5d0 \ub2e4\ub978 \uc720\uc804\uc790\ub97c \uce68\ubb35\uc2dc\ud0a4\ub294 \uc77c\uc774 \uc77c\uc5b4\ub098\uba74 \uc548 \ub41c\ub2e4. \uadf8\ub807\uae30\uc5d0 SIR2 \uc720\uc804\uc790\uc758 \uc0ac\ubcf8\uc744 \ucd94\uac00\ud558\uba74 \uc218\uba85\uc774 \ub298\uace0 \ub354 \uc624\ub798 \ubc88\uc2dd\ud560 \uc218 \uc788\ub2e4. \uc9c4\ud654\uc801\uc73c\ub85c \uc720\ub9ac\ud558\uc9c0 \uc54a\uc558\uae30\uc5d0 \uc774\ub294 \uc790\uc5f0\uc120\ud0dd\uc5d0\uc11c \ubc30\uc81c\ub418\uc5c8\ub2e4. \uc11c\ud22c\uc778\uc740 \uc5d0\ub108\uc9c0\ub97c \ub9ce\uc774 \uc4f0\uae30\uc5d0 \uc0dd\uc874\uc5d0\uc11c \ubd88\ub9ac\ud558\uae30\uae4c\uc9c0 \ud558\ub2e4.
\uc18c\ub098\ubb34\ub294 \uc6b0\ub9ac\uc758 \uc9c4\ud575 \uc138\ud3ec \uc0ac\ucd0c\uc778\ub370, \uadf8\ub4e4\uc740 \ub299\uc9c0 \uc54a\ub294\ub2e4. \uc80a\uc740 \uc18c\ub098\ubb34\uc640 \ub299\uc740 \uc18c\ub098\ubb34\ub294 \uc5b4\ub5a0\ud55c \uc758\ubbf8 \uc788\ub294 \ucc28\uc774\ub3c4 \uc5c6\ub2e4. \ud574\ud30c\ub9ac \uc911 \uc77c\ubd80\ub294 \uc798\ub824 \ub098\uac04 \uc2e0\uccb4 \ubd80\uc704\ub85c\ubd80\ud130 \uc628\uc804\ud788 \uc7ac\uc0dd\ud55c\ub2e4. \ud788\ub4dc\ub77c \uc5ed\uc2dc \ub299\uc9c0 \uc54a\ub294\ub2e4. \uadf8\ub9b0\ub780\ub4dc \uc0c1\uc5b4\ub294 150\uc138\uac00 \ub418\uc5b4\uc57c \uc131\uc801\uc73c\ub85c \uc131\uc219\ud55c\ub2e4. \ubd81\uadf9\uace0\ub798 \uc5ed\uc2dc \uc218\ubc31\ub144\uc744 \uc0b0\ub2e4. \uc138\ud3ec\uc758 \ub098\uc774\ub294 \uc644\uc804\ud788 \uc7ac\uc124\uc815\ub420 \uc218 \uc788\ub2e4. \uc6b0\ub9ac\ub294  \uc7a5\uc218 \uc720\uc804\uc790 -FOXO1,3,4,6\uc744 \uac16\uace0 \uc788\uc74c.
\uc640\ub529\ud134\uc740 \ud6c4\uc131\uc720\uc804\uc801 \uacbd\uad00\uc774 \uc788\ub2e4\uace0 \uc0c1\uc0c1\ud588\ub2e4. \ubc30\uc544 \uc904\uae30\uc138\ud3ec\ub294 \uc0b0\uaf2d\ub300\uae30\uc5d0 \uc788\ub294 \uc870\uc57d\ub3cc\uc774\uace0, \uc774 \uc870\uc57d\ub3cc\uc774 \uad74\ub7ec \ub5a8\uc5b4\uc838\uc11c \uc218\ubc31 \uac1c\uc758 \uace8\uc9dc\uae30\uc911 \ud558\ub098\ub85c \ub5a8\uc5b4\uc9c4\ub2e4. \uc774\ub97c ‘\ubd84\ud654’\ub77c\uace0 \ud55c\ub2e4. \ud6c4\uc131\uc720\uc804\uccb4\ub294 \uc911\ub825\uc758 \uc5ed\ud560\uc744 \ud55c\ub2e4. \uadf8 \uc870\uc57d\ub3cc\uc774 \uadf8 \uace8\uc9dc\uae30\uc5d0 \uc788\ub3c4\ub85d \uc720\uc9c0\ud558\ub294 \uc5ed\ud560\uc774\uc790, \uadf8 \uc870\uc57d\ub3cc\uc744 \ubc11\uc73c\ub85c \ub04c\uc5b4\ub2f9\uae30\ub294 \uc5ed\ud560.
\uacfc\ud559\uc801\uc73c\ub85c \uc124\uba85\ud558\uba74 \ub2e4\uc74c\uacfc \uac19\ub2e4. \uc11c\ud22c\uc778\uacfc \uc804\uc0ac\uc778\uc790, DNMT, HMT \ub4f1\uc758 \uc548\ub0b4\uc5d0 \ub530\ub77c \uac01 \uc720\uc804\uc790\ub4e4\uc774 \ub2e4\ub978 \ubc29\uc2dd\uc73c\ub85c \ucf1c\uc9c0\uace0 \uaebc\uc9d0\uc73c\ub85c\uc368 \ub2e4\ub978 \uc138\ud3ec\ub85c \ubd84\ud654\ud55c\ub2e4.
\uc774 \uc815\ubcf4\uc758 \uc548\uc815\uc131\uc774 \uc6b0\ub9ac\uc758 \uac74\uac15\uc5d0 \uc544\uc8fc \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4. DNA\uc5d0 \uc190\uc0c1\uc774 \uc77c\uc5b4\ub0a0 \ub54c\ub9c8\ub2e4 \uc870\uc57d\ub3cc\uc740 \ub4e4\uc369\uac70\ub9b0\ub2e4. \uc2dc\uac04\uc774 \uc9c0\ub098\uba74\uc11c \uace8\uc9dc\uae30\uac00 \uc595\uc544\uc9d0\uc5d0 \ub530\ub77c \uc870\uc57d\ub3cc\uc774 \ub4e4\uc369\uac70\ub9b4 \ub54c \uc0c8\ub85c\uc6b4 \uace8\uc9dc\uae30\ub85c \ub4e4\uc5b4\uac00\ub294 \uc77c\uc774 \uc0dd\uae34\ub2e4. \uadf8\ub807\uac8c \uac01 \uc138\ud3ec\ub294 \uc7a1\uc74c\uc5d0 \uad74\ubcf5\ud55c\ub2e4. 
\uccb4\ub0b4 NAD \ub18d\ub3c4\uac00 \uc99d\uac00\ud558\uba74 \uc11c\ud22c\uc778 \ud65c\uc131\uc774 \uc99d\uac00\ud55c\ub2e4. NAD \ub18d\ub3c4\uac00 \uc99d\uac00\ud55c \uc0dd\uc950\ub4e4\uc740 \ud2b8\ub808\ub4dc\ubc00\uc774 \ubd80\uc11c\uc9c8 \ub54c\uae4c\uc9c0 \uac8c\uc18d \ub2ec\ub838\ub2e4.<\/p>\n\n\n\n

\ub178\ud654\ub294 \uc9c8\ubcd1\uc774\ub2e4. \ub299\uc5b4\uc11c \uc8fd\ub294 \uc0ac\ub78c\uc740 \uc5c6\ub2e4. \ub299\uc5b4\uc11c \uc5b4\ub518\uac00\uc5d0 \uc9c8\ubcd1\uc774 \uc0dd\uaca8\uc11c \uc8fd\ub294\ub2e4. \uadf8\ub7f0\ub370 \uc6b0\ub9ac\ub294 \uac1c\ubcc4\uc801\uc778 \uc9c8\ubcd1\uc758 \uce58\ub8cc\uc5d0\ub9cc \ucd08\uc810\uc744 \ub9de\ucd94\uc9c0, \ub178\ud654 \uc790\uccb4\ub97c \uc9c8\ubcd1\uc73c\ub85c \ubcfc \uc0dd\uac01\uc740 \uc9c0\uae08\uae4c\uc9c0 \ud558\uc9c0 \ubabb\ud588\uc74c. [\uc791\uac00\ub294 \ub178\ud654\ub294 \uc9c8\ubcd1\uc774\uace0, \uc6b0\ub9ac\ub294 \uc774\ub97c \uce58\ub8cc\ud560 \uc218 \uc788\ub2e4\uace0 \uac15\ud558\uac8c \uc8fc\uc7a5\ud55c\ub2e4. \uadf8\ub9ac\uace0 \ub098 \uc5ed\uc2dc \uadf8\uac00 \uc633\uae30\ub97c \uac04\uc808\ud788 \uc18c\ub9dd\ud55c\ub2e4.]
<\/p>\n\n\n\n

<\/p>\n\n\n\n

\ub178\ud654\uc758 \uc885\ub9d0 – \ub370\uc774\ube44\ub4dc \uc2f1\ud074\ub808\uc5b4<\/strong>
@ \uae30\ubd84 \uc88b\uc740 \ucda9\uaca9\uc744 \uc120\uc0ac\ud558\ub294 \ucc45\uc774\ub2e4. \ub2f9\uc5f0\ud558\uac8c \uc0dd\uac01\ud588\ub358 ‘\ub178\ud654’\uc5d0 \ub300\ud55c \uc0dd\uac01\uc744 \ubc14\uafb8\uac8c \ub410\ub2e4. \ub299\uace0 \ubcd1\ub4e4\uc5b4 \uac00\ub294 \uac74 \ub2f9\uc5f0\ud55c \uc77c\uc774\ub77c\uace0 \uc0dd\uac01\ud588\ub294\ub370, \uc0dd\uac01\ubcf4\ub2e4 \uc608\ubc29\ud560 \ubc29\ubc95\uc774 \ub9ce\ub2e4\uace0 \ub290\uaf08\ub2e4. \uc544\uc9c1 \uc80a\uc740 \ub0a0\uc5d0 \uc774\ub7f0 \uae00\uc744 \uc77d\uac8c \ub418\uc5c8\uc74c\uc5d0 \uac10\uc0ac\ud55c\ub2e4.
\uac00\uc7a5 \ucda9\uaca9\uc801\uc778 \ubd80\ubd84\uc740 \ub178\ud654\uc758 \uc774\ub860\uc774\uc5c8\ub2e4. \uc138\ud3ec\uac00 \ubcf5\uc81c\ub418\uba74\uc11c \uc77c\uc5b4\ub098\ub294 \uc815\ubcf4\uc758 \uc190\uc2e4 \ub54c\ubb38\uc5d0 \ub299\ub294\ub2e4\ub294 \uc0ac\uc2e4. \uadf8\uac83\uc744 \uc6d0\ucd08\uc9c1\uc778 \uc720\uc804\uc790 A\uc640 \uc720\uc804\uc790 B\ub85c \ub098\ub204\uc5b4 \uc124\uba85\ud558\ub294 \uac8c \uc778\uc0c1\uae4a\uc5c8\uc74c.<\/p>\n\n\n\n

. \uc790\uc5f0\uc0ac\ub294 \uc5c6\ub2e4.  \uacb0\uad6d \ub299\uc5b4\uc11c \uc5b4\ub518\uac00 \uace0\uc7a5\uc774 \ub098\uc11c \uc8fd\ub294\ub2e4. \uc8fd\uc74c\uc740 \uc808\ub300\ub85c \ud3c9\ud654\ub86d\uc9c0 \uc54a\uc73c\uba70, \uc624\ud788\ub824 \ud3ed\ub825\uc801\uc774\ub2e4. [\uc791\uac00\ub294 \uc5ec\uae30\uc11c \ub180\ub77c\uc6b4 \uc9c8\ubb38\uc744 \ub358\uc9c4\ub2e4. \uc6b0\ub9ac\uac00 \ub354 \uc80a\uac8c \ub354 \uc624\ub798 \uc0b4 \uc218 \uc788\ub2e4\uba74? \uc0dd\uc560\uc758 \ub9d0\ub144\uc774 \uc55e\uc11c \uc0b0 \uc5ec\ub7ec \ud574\ub4e4\uacfc \uadf8\ub2e4\uc9c0 \ub2e4\ub974\uc9c0 \uc54a\uc544 \ubcf4\uc778\ub2e4\uba74? \uc2dc\uac04\uc774 \ud758\ub7ec\uac10\uc744 \uac71\uc815\ud558\uc9c0 \uc54a\uace0, \uc544\uc774\ucc98\ub7fc \ub354 \uc624\ub798 \uc9c0\ub0bc \uc218 \uc788\ub2e4\uba74? ]
.\uc0b6\uc744 \uc5f0\uc7a5\ud558\ub294 \uac83\uacfc \ud65c\ub825\uc744 \uc5f0\uc7a5\ud558\ub294 \uac74 \ub2e4\ub974\ub2e4. [\uc6b0\ub9ac\ub294 \uc5ec\ub7ec \uc778\uacf5 \uc7a5\uce58\ub4e4\uacfc \ub204\uc6cc \ub354 \uc624\ub798 \uc0b4\uace0 \uc2f6\uc5b4 \ud558\uc9c0 \uc54a\ub294\ub2e4. \uc6b0\ub9ac\ub294 \ub354 \uc80a\uac8c  \uc0b4\uace0 \uc2f6\uc5b4\ud55c\ub2e4. \uadf8\uac83\ub9cc\uc774 \uac00\uce58\uac00 \uc788\ub2e4.]<\/p>\n\n\n\n

1\ubd80. \uc6b0\ub9ac\uac00 \uc54c\uace0 \uc788\ub294 \uac83\ub4e4
[\uc6d0\uc2dc\uc2dc\ub300\ub85c \uac70\uc2ac\ub7ec \uc62c\ub77c\uac00 \uc6b0\ub9ac\uac00 \ub299\ub294 \uc774\uc720\ub97c \uc124\uba85\ud55c\ub2e4]
.\uc6d0\uc2dc \uc9c0\uad6c\uc5d0 \uc788\ub358 \ubd84\uc790\ub4e4\uc774 \ubaa8\uc5ec \ud575\uc0b0\uc744 \uc774\ub8e8\uace0, \ud575\uc0b0\uc774 \ub18d\ucd95\ub418\ub294 \uacfc\uc815\uc5d0\uc11c \uc911\ud569\uccb4polymer\ub97c \ud615\uc131\ud55c\ub2e4. \uc774\ud6c4 RNA\uac00 \ub418\uace0, DNA\uac00 \ub9cc\ub4e4\uc5b4\uc9c4\ub2e4. \ub9cc\ub4e4\uc5b4\uc9c4 \uc720\uc804 \ubb3c\uc9c8\uc774 \uc9c0\ubc29\uc0b0\uc5d0 \uac10\uc2f8\uc774\uba74\uc11c \ubbf8\uc138\ud55c \ube44\ub217\ubc29\uc6b8\ucc98\ub7fc \ub41c\ub2e4. \uc774\uac83\uc758 \uc138\ud3ec\uc758 \ucd5c\ucd08 \ubaa8\uc2b5\uc774\ub2e4. \uc774 \uc6d0\uc2dc \uc138\ud3ec\ub4e4\uc758 \uc77c\ubd80\ub294 \uc6d0\uc2dc\uc801\uc778 \ub300\uc0ac \uacbd\ub85c\ub97c \uac16\ucd94\uae30 \uc2dc\uc791\ud558\uace0, RNA\uc758 \ubcf5\uc81c\uac00 \uc2dc\uc791\ub41c\ub2e4. \uadf8\ub7ec\ub2e4 \ud55c \uc885, magna superstes(\ub9c8\uadf8\ub098 \uc218\ud398\ub974\uc2a4\ud14c\uc2a4 – \uc704\ub300\ud55c \uc0dd\uc874\uc790, \uc791\uac00\uac00 \ubd99\uc778 \uc784\uc758\uc758 \uc774\ub984\uc784) \uc774 \ub0a8\ub294\ub2e4. \uc774 \uc885\uc740 \uc720\uc804\uc801 \uc0dd\uc874 \uba54\ucee4\ub2c8\uc998\uc744 \uac16\uace0 \uc788\ub2e4. \uc774 \uac04\ub2e8\ud55c \uba54\ucee4\ub2c8\uc998\uc740 \ub450 \uac1c\uc758 \uc720\uc804\uc790\ub85c \uc774\ub8e8\uc5b4\uc9c4\ub2e4.
\uc720\uc804\uc790 A\ub294 \ud658\uacbd\uc774 \uc548 \uc88b\uc744 \ub54c \ubc88\uc2dd\uc744 \uba48\ucd94\uac8c \ud55c\ub2e4. \uadf8\ub807\uac8c \ud568\uc73c\ub85c\uc368 \uc0dd\uc874\ub960\uc744 \ub192\uc778\ub2e4.
\uc720\uc804\uc790 B\ub294 \uce68\ubb35\uc2dc\ud0a4\ub294 siilencing \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4e0\ub2e4. \uc774 \uce68\ubb35 \ub2e8\ubc31\uc9c8\uc740 \uc0c1\ud669\uc774 \uc88b\uc744 \ub54c A\uc5d0 \ub2ec\ub77c\ubd99\uc5b4 \uadf8 \uc720\uc804\uc790\ub97c \ub048\ub2e4. \uadf8\ub7ec\uba74 \ubc88\uc2dd\uc744 \uc7ac\uac1c\ud55c\ub2e4.
\uc774 \ub450 \uac00\uc9c0\uc758 \uc720\uc804\uc790\ub294 \uc6d0\uc2dc \uc9c0\uad6c\uc758 \ubaa8\ub4e0 \uc0dd\ubb3c\ub4e4\uc5d0 \uc788\uc5c8\uc73c\ub098, \ub9c8\uadf8\ub098 \uc218\ud398\ub974\uc2a4\ud14c\uc2a4\uc758 \ub3c5\ud2b9\ud55c \uc810\uc740, \uc720\uc804\uc790 B\uc5d0 \uae30\ub2a5\uc774 \ud558\ub098 \ucd94\uac00\ub418\uc5c8\ub2e4\ub294 \uac83. DNA\uc758 \uc218\uc120\uc744 \ub3d5\ub294\ub2e4. \uc138\ud3ec\uc758 DNA\uac00 \uc190\uc0c1\ub418\uba74 B\uac00 \ub9cc\ub4dc\ub294 \uce68\ubb35 \ub2e8\ubc31\uc9c8\uc774 \uc218\uc120\uc744 \ub3d5\uae30 \uc704\ud574 \uc6d0\ub798 \ubd99\uc5b4 \uc788\ub358 \uc720\uc804\uc790 A\ub97c \ub5a0\ub09c\ub2e4. \uadf8\ub807\uac8c \ud568\uc73c\ub85c\uc368 DNA\uac00 \uc190\uc0c1\ub418\uc5c8\uc73c\uba74 \ubc88\uc2dd\uc744 \uba48\ucd94\uace0, DNA \uc218\uc120\uc774 \uc644\ub8cc \ub418\uba74 \ubc88\uc2dd\uc744 \uc7ac\uac1c\ud55c\ub2e4.
\uc774\ud6c4 \uc6d0\uc2dc \uc9c0\uad6c\uc5d0 \uc6b0\uc8fc\uc120\uc774 \ub0b4\ub9ac\ucb14\ub2e4. \uadf8\ub7fc\uc73c\ub85c\uc368 DNA\uc5d0 \uc190\uc0c1\uc774 \uc77c\uc5b4\ub098\uace0, \uc190\uc0c1\uc744 \ud68c\ubcf5\ud560 \ud68c\ub85c\ub97c \uac16\uace0 \uc788\uc9c0 \uc54a\uc740 \ub2e4\ub978 \uc0dd\uba85\uccb4\ub4e4\uc740 \uc190\uc0c1\ub41c DNA\ub85c \ubcf5\uc81c\ub97c \uc2dc\uc791\ud558\uace0, \ubaa8\ub450 \uc8fd\uc5b4\uc11c \uc0ac\ub77c\uc9c4\ub2e4. \uc774\ud6c4 \uac74\uae30\uac00 \ub05d\ub098\uace0, \ub2e4\uc2dc \ud638\uc218\uc5d0 \ubb3c\uc774 \ucc28\uba74 \ubc88\uc2dd\uc744 \uc7ac\uac1c\ud55c\ub2e4.
\/\/ \uc774\uac83\uc774 \uc2e4\uc874 \uc0dd\ubb3c\uc778\uc9c0\ub294 \uc544\ubb34\ub3c4 \ubaa8\ub974\ub098, \uc800\uc790\uc758 25\ub144 \uc5f0\uad6c\ub294 \uc774\uc640 \ub3d9\uc77c\ud558\uac70\ub098 \ube44\uc2b7\ud55c \uc0dd\ubb3c\uc758 \uc874\uc7ac\ub97c \uc554\uc2dc\ud55c\ub2e4\uace0 \ud568. \uc9c0\uad6c\uc5d0 \uc0ac\ub294 \ubaa8\ub4e0 \uc0dd\ubb3c\uc740 \ub3d9\uc77c\ud55c \ud615\ud0dc\ub85c \uace0\ub300\uc758 \uc774 \uc720\uc804\uc801 \ud68c\ub85c\ub97c \uc5ec\uc804\ud788 \uc9c0\ub2c8\uace0 \uc788\ub2e4. \ubaa8\ub4e0 \uc2dd\ubb3c, \uacf0\ud321\uc774, \ub3d9\ubb3c, \uc778\uac04\uc5d0\uac8c \ub4e4\uc5b4\uc788\ub2e4.
\uc774 \uc0dd\uc874 \ud68c\ub85c\ub294 \uc6b0\ub9ac\uac00 \uc0b4\uc544\ub0a8\uac8c \ud558\ub294 \uae30\uc801\uc744 \ub9cc\ub4e4\uc5b4 \ub0c8\uc73c\ub098, \uc6b0\ub9ac\ub97c \ub299\uac8c \ub9cc\ub4e4\uae30\ub3c4 \ud55c\ub2e4. \ub178\ud654\uc758 \uc6d0\uc778\uc740 \ub2e8 \ud55c\uac00\uc9c0, \uc774\uac83\uc774\ub2e4.<\/p>\n\n\n\n

\ub299\ub294 \uc774\uc720\uc5d0 \ub300\ud55c \uacfc\uac70\uc758 \uace0\ucc30\ub4e4
. \uc0dd\ubb3c\uc774 \uc885\uc744 \uc704\ud574 \ub299\uc5b4 \uc8fd\ub294\ub2e4\uace0 \ub110\ub9ac \ubc1b\uc544\ub4e4\uc5ec\uc84c\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub294 \uc644\uc804\ud788 \ud2c0\ub838\ub2e4. \uac1c\uccb4\ub294 \uc790\uae30 \ubcf4\uc804\uc744 \ucd94\uad6c\ud55c\ub2e4. \uac00\ub2a5\ud55c \ud55c \uc77c\ucc0d, \uac00\ub2a5\ud55c \ud55c \uc624\ub798 \ubc88\uc2dd\uc744 \ud558\ub824\uace0 \uc560\uc4f4\ub2e4.
. \ud1a0\uba38\uc2a4 \ucee4\ud06c\uc6b0\ub4dc -> \uc77c\ud68c\uc6a9 \uccb4\uc138\ud3ec \uac00\uc124\/ \uc790\uc6d0\uc740 \ud55c\uc815\ub418\uc5b4 \uc788\uae30\uc5d0, \ubc88\uc2dd\uacfc \uc0dd\uc874 \uc911 \ud558\ub098\ub97c \uc120\ud0dd\ud574\uc57c \ud55c \ub2e4. \uc77c\ucc0d \ubc88\uc2dd\ud558\uace0 \uc77c\ucc0d \uc8fd\uac70\ub098, \ub2a6\uac8c \ubc88\uc2dd\ud558\uba74\uc11c \ubab8\uc744 \uc720\uc9c0\ud558\uac70\ub098.
  \uc774 \uac00\uc124\uc740 \uc124\ub4dd\ub825 \uc788\ub294 \uc0ac\ub840\ub85c \uc124\uba85\ub41c\ub2e4. \ub2f9\uc2e0\uc774 \uc7a1\uc544\uba39\ud790 \ud655\ub960\uc774 \ub192\uc740 \uc124\uce58\ub958\ub77c\uba74, \uc720\uc804\uc790\ub97c \ube68\ub9ac \ud6c4\ub300\ub85c \uc804\ub2ec\ud560 \ud544\uc694\uac00 \uc788\ub2e4. \ub354 \uc624\ub798 \uc0ac\ub294 \ubab8\uc740 \ub2f9\uc2e0\uc758 \uc885\uc5d0\uc11c \ud37c\uc9c0\uc9c0 \uc54a\uc558\ub2e4. \uc624\ub798 \uc0b4\uba74, \ud2bc\ud2bc\ud558\uc9c0 \ubabb\ud55c \ubab8\uc77c\ud14c\ub2c8 \ud3ec\uc2dd\uc790\ub97c \uc7a5\uae30\uac04 \ud53c\ud560 \uc218 \uc5c6\uc5c8\uc744 \ud14c\ub2c8\uae4c.
\ubc18\ub300\ub85c \ub2f9\uc2e0\uc774 \uba39\uc774\uc0ac\uc2ac\uc758 \uaf2d\ub300\uae30\uc5d0 \uc788\ub294 \ub9f9\uae08\ub958\ub77c\uace0 \ud558\uba74, \ub2f9\uc2e0\uc758 \uc720\uc804\uc790\ub294 \uc218\uc2ed\ub144 \ub3d9\uc548 \ubc88\uc2dd\ud560 \uc218 \uc788\ub294 \ud2bc\ud2bc\ud558\uace0 \uc624\ub798 \uc720\uc9c0\ub41c\ub290 \ubab8\uc744 \ub9cc\ub4e4 \ub54c \ud61c\ud0dd\uc744 \ubcf8\ub2e4. \uadf8 \ub300\uc2e0 \ud55c \ud574\uc5d0 \uc0c8\ub07c\ub97c \ub9ce\uc774 \uae30\ub97c \uc5ec\uc720\ub294 \uc5c6\ub2e4. [ \uc0dd\uc950\ub294 \uaca8\uc6b0 3\ub144\uc744 \uc0ac\ub294\ub370, \uc5b4\ub5a4 \uc0c8\ub4e4\uc740 100\ub144\uae4c\uc9c0 \uc0b0\ub2e4\uace0 \ud568. \uc774 \uc5bc\ub9c8\ub098 \ub180\ub77c\uc6b4 \ud1b5\ucc30\uc778\uac00?]
\uc0dd\ubb3c\uc774 \uc720\uc804\uc790\ub97c \uc131\uacf5\uc801\uc73c\ub85c \uc804\ub2ec\ud558\uba74 \uc790\uc5f0\uc120\ud0dd\uc774 \ubd88\uba78\uc744 \uc120\ud0dd\ud558\uc9c0 \uc54a\ub294\ub2e4. \uc790\uc6d0\uc774 \ud55c\uc815\ub418\uc5b4 \uc788\uae30\uc5d0 \ubc88\uc2dd\uc774\ub098 \uc218\uba85 \uc911 \ud558\ub098\uc5d0 \ud560\ub2f9\ud654\ub85d \uc9c4\ud654\ud588\uae30 \ub54c\ubb38. \ubaa8\ub4e0 \uc885\ub4e4\uc740 \uadf8\ub7ec\ud588\uc73c\ub098, \ud638\ubaa8 \uc0ac\ud53c\uc5d4\uc2a4\ub294 \ucee4\ub2e4\ub780 \ub1cc\uc640 \ubc88\ucc3d\ud558\ub294 \ubb38\uba85\uc744 \ud65c\uc6a9\ud574 \uc9c4\ud654\uc801\uc73c\ub85c \ubd88\ub9ac\ud55c \uc57d\uc810\ub4e4\uc744 \uadf9\ubcf5\ud558\uba74\uc11c \ud601\uc2e0\uc744 \uacc4\uc18d\ud574 \uc654\ub2e4. \uc218\uba85\uc744 \uc810\uc810 \ub298\ub9ac\ub294 \uac83.<\/p>\n\n\n\n

\ub178\ud654 \uc774\ub860\uc758 \uadfc\ubcf8\uc801\uc778 \uc124\uba85
. \ub178\ud654\uc758 \ud1b5\uc77c\ub41c \uc774\ub860\uc774 \ud544\uc694\ud558\ub2e4.
. \ud53c\ud130 B. \uba54\ub354\uc6cc\uc640 \ub808\uc624 \uc2e4\ub77c\ub974\ub4dc\uac00 \uc81c\uc2dc\ud55c \uac00\uc124 : \ub178\ud654\uac00 DNA \uc190\uc0c1\uacfc \uadf8\uc5d0 \ub530\ub978 \uc720\uc804 \uc815\ubcf4\uc758 \uc0c1\uc2e4\ub85c \uc0dd\uae34\ub2e4
.  \ub808\uc2ac\ub9ac \uc624\uac94 : \uc624\ub958 \ud30c\uad6d \uac00\uc124 ERROR CATASTROPHE HYPOTHESIS  DNA \ubcf5\uc81c \uacfc\uc815\uc5d0\uc11c \uc77c\uc5b4\ub09c \uc624\ub958\uac00 \uc720\uc804\uc790\uc5d0 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uc77c\uc73c\ud0a4\uace0, \uadf8\uc5d0 \ub530\ub77c \ubcf5\uc81c \uacfc\uc815\uc774 \uc810\uc810 \uad50\ub780\ub418\uba74\uc11c \ubcf5\uc81c\uac00 \ubd80\uc815\ud655\ud558\uac8c \uc774\ub904\uc9c4\ub2e4.
. \ub370\ub118 \ud558\uba3c -\ub178\ud654\uac00 \uc138\ud3ec \ub0b4\uc758 \uc790\uc720 \ub77c\ub514\uce7c \uc804\uc790 \ub54c\ubb38\uc5d0 \uc77c\uc5b4\ub09c\ub2e4. \uc0b0\ud654\ub97c \uc77c\uc73c\ucf1c\uc11c DNA \ub97c \uc190\uc0c1\uc2dc\ud0a4\uae30 \ub54c\ubb38. [\ud754\ud788 \ud65c\uc131 \uc0b0\uc18c\ub77c\uace0 \ubd80\ub974\ub294 \uac83\ub4e4] 
\/\/ \ud56d\uc0b0\ud654\uc81c\uac00 \uc218\uba85\uc744 \ub298\ub9ac\ub294\uc9c0 \uacc4\uc18d \uc870\uc0ac\ud588\uc73c\ub098, \uc5b4\ub5a4 \ud56d\uc0b0\ud654\uc81c\ub3c4 \ucd5c\ub300 \uc218\uba85\uc744 \ub298\ub9ac\uc9c0 \ubabb\ud588\ub2e4. \ud3c9\uade0\uc218\uba85\uc740 \ub298\uc5c8\uc74c. \uadf8\ub7ec\ub098 \uc544\uc9c1\ub3c4 \ud65c\uc131\uc0b0\uc18c\ub97c \uc5c6\uc560\ub294 “\ud56d\uc0b0\ud654”\ub77c\ub294 \ud0a4\uc6cc\ub4dc\ub294 \ub110\ub9ac \ud314\ub9ac\ub294 \uac74\uac15\uc2dd\ud488 \ud0a4\uc6cc\ub4dc\ub2e4.
. \uc2e4\ub77c\ub974\ub4dc\ub294 \uc778\uac04 \uc138\ud3ec\uc758 \ud074\ub860\uc744 \ub9cc\ub4e4\uc5b4 \ub0c4\uc73c\ub85c\uc368 \uc790\uc2e0\uc758 \uac00\uc124\uc744 \ubc18\uc99d\ud588\ub2e4. \ub299\uc740 \uc138\ud3ec\uac00 \uc911\uc694\ud55c \uc720\uc804 \uc815\ubcf4\ub97c \uc783\uc5b4\ubc84\ub838\ub2e4\uba74, \ub299\uc740 \uac1c\uccb4\ub85c\ubd80\ud130 \ubcf5\uc81c\ub41c \uac1c\uccb4\ub294 \uc5ec\uc804\ud788 \ub299\uc5b4 \uc788\uc5b4\uc57c \ud55c\ub2e4. \ud558\uc9c0\ub9cc \uadf8\ub7ec\uc9c0 \uc54a\uc558\uc74c.
\uace0\ub85c, \ub178\ud654\ub294 \uc0b0\ud654\ub85c \uc778\ud55c DNA(\ud2b9\ud788 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 DNA)\uc758 \uc190\uc0c1 \ub54c\ubb38\ub3c4 \uc544\ub2c8\uace0, \uc138\ud3ec\ud575 DNA\uc758 \ub3cc\uc5f0\ubcc0\uc774 \ub54c\ubb38\ub3c4 \uc544\ub2c8\ub2e4.<\/p>\n\n\n\n

.\uacfc\ud559\uc801 \ud569\uc758 : \ub178\ud654\uc640 \uc218\ubc18\ub418\ub294 \uc9c8\ubcd1\uc740 \ub178\ud654\uc758 \uc5ec\ub7ec \uc9d5\ud45c\ub4e4\uc758 \uc0b0\ubb3c\uc774\ub2e4.
\uc9d5\ud45c\ub4e4 : 1. DNA \uc190\uc0c1\uc73c\ub85c \uc778\ud55c \uc720\uc804\uc801 \ubd88\uc548\uc815
2. \ud154\ub85c\ubbf8\uc5b4\uc758 \ub9c8\ubaa8
3. \uc5b4\ub290 \uc720\uc804\uc790\uac00 \ucf1c\uc9c0\uace0 \uaebc\uc9c8\uc9c0\ub97c \uc870\uc808\ud558\ub294 \ud6c4\uc131\uc720\uc804\uccb4epigenome\uc758 \ubcc0\ud654[ \uc720\uc804\uc790 B\uaca0\uc8e0?]
4. \ub2e8\ubc31\uc9c8\uc744 \uac74\uac15\ud558\uac8c \uc720\uc9c0\ud558\ub294 \ub2a5\ub825(\ub2e8\ubc31\uc9c8 \ud56d\uc0c1\uc131 proteostasis)\uc758 \uc0c1\uc2e4
5. \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544 \uae30\ub2a5 \uc774\uc0c1
6. \ub300\uc0ac \ubcc0\ud654\ub85c \uc0dd\uae30\ub294 \uc601\uc591\uc18c \uac10\uc9c0 \ub2a5\ub825\uc758 \ud63c\ub780
7. \uac74\uac15\ud55c \uc138\ud3ec\uc5d0 \uc5fc\uc99d\uc744 \uc77c\uc73c\ud0a4\ub294 \ub178\ud654 \uc138\ud3ec\uc758 \ucd95\uc801
8. \uc904\uae30\uc138\ud3ec\uc758 \uc18c\uc9c4
9. \uc138\ud3ec \ub0b4 \uc758\uc0ac\uc18c\ud1b5\uc758 \ubcc0\ud615\uacfc \uc5fc\uc99d \ubd84\uc790\uc758 \uc0dd\uc131
\uc9c0\ub09c \uba87 \uc2ed\ub144 \uac04, \uacfc\ud559\uc790\ub4e4\uc740 \uc774 \uac01\uac01\uc758 \uc9d5\ud45c\ub4e4\uc5d0 \ub300\uc751\ud558\ub294 \uac8c \ub178\ud654\ub97c \ub9c9\ub294 \ucd5c\uc120\uc774\ub77c\uace0 \uc0dd\uac01\ud588\ub2e4. \uc774\ub7f0 \uc9d5\ud45c\ub4e4\uacfc \uc99d\uc0c1\ub4e4\uc774 \ub178\ud654\uc758 \uc9c0\ud45c\uc784\uc744 \ud655\uc2e0\ud558\uace0 \uc788\uc73c\ub098, \uc544\uc9c1 \uc6b0\ub9ac\ub294 \uc774\ub7f0 \uc9d5\ud45c\ub4e4\uc774 \uc65c \uc0dd\uaca8\ub098\ub294\uc9c0\ub294 \uc124\uba85\ud560 \uc218\uac00 \uc5c6\ub2e4.<\/p>\n\n\n\n

“\uc6b0\ub9ac\ub294 \uc65c \ub299\ub294\uac00?”\uc5d0 \ub300\ud55c \ub2e8\uc77c\ud55c \ub300\ub2f5 – \ub178\ud654\uc758 \uc815\ubcf4 \uc774\ub860
<\ub178\ud654\ub294 \uc815\ubcf4\uc758 \uc0c1\uc2e4\uc774\ub2e4> \/\uc2e4\ub77c\ub974\ub4dc\uc640 \uba54\ub354\uc6cc\uc758 \uac1c\ub150\uacfc\ub294 \ub2e4\ub974\ub2e4. \uadf8\ub4e4\uc740 ‘\uc720\uc804 \uc815\ubcf4\uc758 \uc0c1\uc2e4’\uc5d0 \ucd08\uc810\uc744 \ub9de\ucdc4\ub2e4. \uadf8\ub7ec\ub098 \uc720\uc804 \uc815\ubcf4\ub294 \uc0c1\uc2e4\ub418\uc9c0 \uc54a\ub294\ub2e4.
\uc0dd\ubb3c\uc5d0\uac8c\ub294 \ub450 \uc885\ub958\uc758 \uc815\ubcf4\uac00 \uc788\ub2e4. \uccab \uc720\ud615\uc758 \uc815\ubcf4\ub294 \ub514\uc9c0\ud138, \uc989 A, G, T,C\ub85c \uc774\ub904\uc9c4 \uc0ac\uc9c4\uc218 \ucf54\ub4dc\ub97c \uc4f4\ub2e4. \ub514\uc9c0\ud138 \uc815\ubcf4\ub294 \uc815\ubcf4\uc758 \uc800\uc7a5\uacfc \ubcf5\uc81c\ub97c \uc2e0\ub8b0\ud560 \uc218 \uc788\ub2e4. (\ub9c8\uce58 \ucef4\ud4e8\ud130 \ud558\ub4dc\ub514\uc2a4\ud06c \uac19\uc740 \uac83\ucc98\ub7fc) \ub610\ud55c, \ud2bc\ud2bc\ud558\ub2e4. \ub053\ub294 \ubb3c\uc5d0\uc11c \uba87 \uc2dc\uac04 \ub3d9\uc548 \uacac\ub51c \uc218 \uc788\uc73c\uba70, 4\ub9cc\ub144 \ub41c \uc778\ub958\uc758 \ubf08\uc5d0\uc11c \ucd94\ucd9c\ud560 \uc218\ub3c4 \uc788\ub2e4. \uc720\uc804 \uc815\ubcf4\ub294 DNA\uc5d0 \ub514\uc9c0\ud138 \ubc29\uc2dd\uc73c\ub85c \uc800\uc7a5\ub41c\ub2e4.
\ub450 \ubc88\uc9f8 \uc720\ud615\uc758 \uc815\ubcf4\ub294 \uc544\ub0a0\ub85c\uadf8 \ud615\ud0dc\ub2e4. \uc624\ub298\ub0a0 \ud754\ud788 \ud6c4\uc131\uc720\uc804\uccb4epigenome\ub77c\uace0 \ubd88\ub9b0\ub2e4. \uc720\uc804\uc801 \uc218\ub2e8\uc744 \ud1b5\ud574 \uc804\ub2ec\ub418\uc9c0 \uc54a\ub294 \uc720\uc804 \uac00\ub2a5\ud55c \ud615\uc9c8(..? \ubb54\uc18c\ub9ac\uc57c) \ud6c4\uc131\uc720\uc804 \uc815\ubcf4\ub294 \uc5fc\uc0c9\uc9c8(DNA\uc640 \ud788\uc2a4\ud1a4 \ub2e8\ubc31\uc9c8\ub85c \uad6c\uc131\ub41c \ubcf5\ud569\uccb4)\uc5d0 \uc800\uc7a5\ub41c\ub2e4. \uc774 \ud6c4\uc131\uc720\uc804 \uc815\ubcf4\uc758 \uc800\uc7a5\uacfc \uc804\ub2ec\uc740 \uc0dd\uc874\uc5d0 \ud544\uc218\uc801\uc774\ub2e4. \uc774 \ud6c4\uc131 \uc720\uc804 \uc815\ubcf4\ub294 \ud558\ub098\uc758 \uc218\uc815\ub780\uc5d0\uc11c 260\uc5b5 \uac1c\uc758 \uc138\ud3ec\ub85c \uc774\ub904\uc9c4 \uc2e0\uc0dd\uc544\uac00 \ub418\uae30\uae4c\uc9c0\uc758 \ubc1c\uc0dd \uacfc\uc815\uc744 \uc870\uc728\ud558\uace0, \uc720\uc804\uc801\uc73c\ub85c \ub3d9\uc77c\ud55c \uc138\ud3ec\ub4e4\uc774 \uc6b0\ub9ac \ubab8\uc5d0\uc11c \uc218\ucc9c\uac00\uc9c0 \uc138\ud3ec\ub85c \ubd84\ud654\ud560 \uc218 \uc788\ub3c4\ub85d \ud55c\ub2e4.
\ud6c4\uc131\uc720\uc804 \uc815\ubcf4\ub294 \uc18c\ud504\ud2b8\uc6e8\uc5b4\ub77c\uace0 \ubcf4\uba74 \ub41c\ub2e4. \ubd84\uc5f4\ub41c \uc138\ud3ec\uac00 \uc5b4\ub5a4 \uc885\ub958\uc758 \uc138\ud3ec\ub85c \ubc1c\ub2ec\ud560\uc9c0 \uc9c0\uc2dc\ud558\uace0, \ud55c \uc885\ub958\uc758 \uc138\ud3ec\uac00 \uc218\uc2ed \ub144 \ub3d9\uc548 \uc815\uccb4\uc131\uc744 \uc720\uc9c0\ud558\ub3c4\ub85d \ud574 \uc900\ub2e4. (\uc608\uc2dc : \ub274\ub7f0\uc774 \uac11\uc790\uae30 \ud53c\ubd80\uc138\ud3ec\ucc98\ub7fc \ud589\ub3d9\ud558\uc9c0 \uc54a\uace0, \ubd84\uc5f4\ud558\ub294 \ucf69\ud325 \uc138\ud3ec\uac00 \uac11\uc790\uae30 \uc2ec\uc7a5\uc138\ud3ec\uac00 \ub418\uc9c0 \uc54a\ub294 \uc774\uc720.)
\uc6d0\uc2dc\uc9c0\uad6c\uc5d0\uc11c \ub514\uc9c0\ud138 \ubc29\uc2dd\uc740 \uc720\uc804 \uc815\ubcf4\ub97c \uc7a5\uae30\uac04 \uc800\uc7a5\ud558\ub294 \ucd5c\uace0\uc758 \ubc29\ubc95\uc774\uc5c8\ub2e4. \uadf8\ub7ec\ub098 \ud658\uacbd \uc870\uac74\uc744 \uae30\ub85d\ud558\uace0 \uac70\uae30\uc5d0 \ubc18\uc751\ud558\ub294 \ub370 \ud544\uc694\ud55c \uc815\ubcf4\ub294 \uc544\ub0a0\ub85c\uadf8 \ubc29\uc2dd\uc73c\ub85c \uc800\uc7a5\ud558\ub294 \uac8c \ucd5c\uc120\uc774\uc5c8\ub2e4. \uc27d\uac8c \uaebc\ub0b4\uace0 \uc800\uc7a5\ud558\uace0 \uc218\uc815\ud560 \uc218 \uc788\uae30\uc5d0 \ubb34\ud55c\ud55c \uac00\ub2a5\uc131\uc744 \uac00\uc9c0\uae30 \ub54c\ubb38.
\uadf8\ub7ec\ub098 \uc774\ub807\uac8c \uc544\ub0a0\ub85c\uadf8 \ud615\uc2dd\uc73c\ub85c \uc800\uc7a5\ud55c \uc815\ubcf4\ub294 \uc2dc\uac04\uc774 \ud750\ub974\uba74\uc11c \ubcc0\uc9c8\ub41c\ub2e4. \uc790\uae30\uc7a5, \uc911\ub825, \uc6b0\uc8fc\uc120, \uc0b0\uc18c \ub4f1\uc5d0 \uc758\ud574. \uac8c\ub2e4\uac00 \ubcf5\uc81c\ud558\uba74\uc11c \uc77c\ubd80\ub97c \uc783\ub294\ub2e4.
\uc6b0\ub9ac\ub294 \uae68\uc9c4 DVD\ub85c\ubd80\ud130 \uc815\ubcf4\ub97c \ubcf5\uc6d0\ud560 \uc218\ub294 \uc5c6\uc73c\ub098, \uae01\ud78c DVD\ub294 \uc815\ubcf4\ub97c \ubcf5\uc6d0\ud560 \uc218 \uc788\ub2e4. \uc791\uac00\ub294 \ub178\ud654 \uc5ed\uc2dc \uac00\ub2a5\ud558\ub2e4\uace0 \uc0dd\uac01\ud55c\ub2e4. \ubcf5\uc81c \uc0dd\ubb3c\uc774 \uc99d\uba85\ud588\ub4ef\uc774, \uc6b0\ub9ac\uac00 \ub299\uc5b4\ub3c4 \uc0dd\ubb3c\uc740 \uc5ec\uc804\ud788 \uc80a\uc744 \ub54c\uc758 \ub514\uc9c0\ud138 \uc815\ubcf4\ub97c \uac16\uace0 \uc788\ub2e4. \ub2e4\uc2dc \uc80a\uc5b4 \uc9c0\ub824\uba74 \uadf8 \uc815\ubcf4\ub97c \ucc3e\uae30\ub9cc \ud558\uba74 \ub41c\ub2e4.
[\uc774 \ucc45\uc5d0\uc11c \uc774 \ub0b4\uc6a9\uc774 \uac00\uc7a5 \uc8fc\ub41c \ub0b4\uc6a9\uc774\ub2e4. \uac00\uc7a5 \ud601\uc2e0\uc801\uc778 \ub0b4\uc6a9\uc774\uae30\ub3c4 \ud558\ub2e4. \ub0b4\uac00 \uc0c1\uc0c1\ub3c4 \ubabb\ud55c \ubc29\uc2dd\uc73c\ub85c \ub178\ud654\ub97c \uc815\uc758\ud558\uace0, \ub610\ud55c \uadf8 \uadfc\uac70 \uc5ed\uc2dc \ud0c4\ud0c4\ud558\ub2e4. \ubaa8\ub4e0 \ucc45\uc758 \ub0b4\uc6a9\uc740 \uc5ec\uae30\uc11c \uc2dc\uc791\ud55c\ub2e4. ]<\/p>\n\n\n\n

\uc6d0\uc2dc\uc801\uc778 \uc0dd\uc874 \ud68c\ub85c(\uc720\uc804\uc790 A\uc640 \uc720\uc804\uc790 B)\ub294 \uc2dc\uac04\uc774 \ud750\ub974\uba74\uc11c \uc544\uc8fc \ubcf5\uc7a1\ud574\uc84c\uace0, \uc6b0\ub9ac\ub294 22\uac1c \uc774\uc0c1\uc758 \uadf8\ub7f0 \uc720\uc804\uc790\ub97c \uac16\uace0 \uc788\ub2e4. \uc774\ub7ec\ud55c \uc720\uc804\uc790\ub294 \uc0b6\uc744 \ub298\ub9ac\uace0, \ub354 \uac74\uac15\ud558\uac8c \ub9cc\ub4e0\ub2e4. \uc774 \uc720\uc804\uc790\ub4e4\uc740 \ubab8\uc744 \uad6c\uc131\ud558\ub294 \uc138\ud3ec\ub4e4\uacfc \uae30\uad00\ub4e4\uc774 \uc758\uc0ac\uc18c\ud1b5\uc744 \ud558\uac8c \ud558\ub294 \uc77c\uc885\uc758 \uac10\uc2dc\ub9dd\uc744 \ud615\uc131\ud55c\ub2e4. \uc0c1\ud669\uc774 \uc548 \uc88b\uc73c\uba74 \uc7a0\uc2dc \uc228\uc8fd\uc774\uace0 \uc788\uc73c\ub77c\uace0 \ud558\uace0, \uc0c1\ud669\uc774 \ub098\uc544\uc9c0\uba74 \ube68\ub9ac \uc131\uc7a5\ud574 \ubc88\uc2dd\ud558\ub77c\uace0 \ub9d0\ud55c\ub2e4.
\uc7a5\uc218 \uc720\uc804\uc790\ub294 sirtuin(\uc11c\ud22c\uc778)\uc774\ub77c\ub294 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4e0\ub2e4.\ud6a8\ubaa8\uc5d0\uc11c sir2 \uc720\uc804\uc790\uac00 \ucc98\uc74c \ubc1c\uacac\ub418\uc5c8\ub2e4. \ud3ec\uc720\ub958\ub294 sirt1 \uc5d0\uc11c sirt7\uae4c\uc9c0 \uc788\ub2e4. \uc774\ub294 \ubaa8\ub4e0 \uc138\ud3ec\uc5d0\uc11c \ub9cc\ub4e4\uc5b4\uc9c4\ub2e4. \uc11c\ud22c\uc778\uc740 \uc6d0\uc2dc \uc0dd\uc874\ud68c\ub85c\uc758 \uc720\uc804\uc790 B\uc758 \ud6c4\uc190\uc73c\ub85c\uc368, \ub2e8\ubc31\uc9c8\uc5d0\uc11c \uc544\uc138\ud2f8\uae30 \uaf2c\ub9ac\ud45c\ub97c \uc81c\uac70\ud55c\ub2e4. \uadf8\ub7fc\uc73c\ub85c\uc368 \ud544\uc694\ud560 \ub54c \uc5b4\ub5a4 \uc720\uc804\uc790\ub97c \ucf1c\uac70\ub098 \ub048\ub2e4. \uc774 \ub2e8\ubc31\uc9c8\uc740 \uc138\ud3ec \uc81c\uc5b4 \uc2dc\uc2a4\ud15c\uc758 \ucd5c\uc0c1\uc704\uc5d0 \uc704\uce58\ud558\uace0, \ubc88\uc2dd\uacfc DNA\uc218\uc120\uc744 \uc81c\uc5b4\ud55c\ub2e4. \uc774\ub4e4\uc740 NAD : nicotinamide adenine dinucleotide\ub77c\ub294 \ubd84\uc790\ub97c \uc774\uc6a9\ud55c\ub2e4. \ub098\uc774\ub97c \uba39\uc744\uc218\ub85d NAD\ub294 \uc904\uc5b4\ub4e4\uace0, \uadf8\ub85c \uc778\ud574 \uc11c\ud22c\uc778 \ub2e8\ubc31\uc9c8\uc758 \ud65c\uc131\uc774 \uac10\uc18c\ub41c\ub2e4. \uc774\uac83\uc774 \ubc14\ub85c \ub178\ud654\uc758 \uc6d0\uc778\uc774\ub77c\uace0 \uc5ec\uaca8\uc9c4\ub2e4.
\uc11c\ud22c\uc778\uc740 \uc2a4\ud2b8\ub808\uc2a4\ub97c \ubc1b\uc744 \ub54c \ubc88\uc2dd \ub300\uc2e0 \uc218\uc120\uc5d0 \uc9d1\uc911\ud558\uae30 \uc704\ud574 “\ud5c8\ub9ac\ub760\ub97c \uc870\uc774\uace0” \ub178\ud654\uc758 \uc8fc\uc694 \uc9c8\ubcd1\ub4e4\uacfc, \uc5ec\ub7ec \uc5fc\uc99d\ubc18\uc751\uc5d0 \ub9de\uc120\ub2e4. \uae30\ud0c0 \ub4f1\ub4f1 \uc548 \uc88b\uc740 \uac83\ub4e4\uc5d0 \ub300\ud56d\ud55c\ub2e4.
\\  \ube44\uc2b7\ud55c \ub2e8\ubc31\uc9c8\ub85c TOR target of rapamycin\uc774\ub77c\ub294 \ub2e8\ubc31\uc9c8\uc774 \uc788\uc74c. \uc11c\ud22c\uc778\uc740 \uc5ec\ub7ec \uc7a5\uc218 \uc720\uc804\uc790 \uc911 \uc791\ub3d9\uc774 \uac04\ub2e8\ud558\uace0, \uc870\uc791\ud560 \uc218 \uc788\uc74c. mTOR(\ud3ec\uc720\ub958\uc758 TOR)\uc740 \ubaa8\ub4e0 \uc0c1\ud669\uc774 \uc88b\uc744 \ub54c, \uac00\uc6a9 \uc544\ubbf8\ub178\uc0b0\uc758 \uc591\uc744 \uac10\uc9c0\ud558\uace0 \uadf8\uc5d0 \ubc18\uc751\ud574 \ub2e8\ubc31\uc9c8\uc744 \uc5bc\ub9c8\ub098 \ub9cc\ub4e4\uc9c0 \uc9c0\uc815\ud55c\ub2e4. \uadf8\ub7ec\ub098 \uc0c1\ud669\uc774 \uc548 \uc88b\uc73c\uba74 \ubd84\uc5f4\uc744 \uba48\ucd94\uace0 \uae30\uc874\uc758 \uc138\ud3ec \uc131\ubd84\ub4e4\uc744 \uc7ac\ud65c\uc6a9\ud574 \uc0dd\uc874\uc744 \ub3c4\ubaa8\ud55c\ub2e4.
\ube44\uc2b7\ud55c \ub2e8\ubc31\uc9c8\ub85c AMPK\uac00 \uc788\ub2e4. AMP-activated protein kinase\/ \uc5d0\ub108\uc9c0\uac00 \uc801\uc744 \ub54c \ubc18\uc751\ud55c\ub2e4.
\uc774\ub7ec\ud55c \ubc29\uc5b4 \uccb4\uacc4\ub4e4\uc740 \ubaa8\ub450 \uc0dd\ubb3c\ud559\uc801 \uc2a4\ud2b8\ub808\uc2a4\uc5d0 \ubc18\uc751\ud574 \ud65c\uc131\ud654\ub41c\ub2e4. \uc5b4\ub5a4 \uc2a4\ud2b8\ub808\uc2a4\ub294 \uadf9\ubcf5\ud558\uae30 \ud798\ub4e4\ub2e4. \uae09\uc131 \uc678\uc0c1\uc774\ub098 \ud1b5\uc81c \ubd88\ub2a5\uc758 \uac10\uc5fc\uc740 \ub178\ud654\uc640 \ubb34\uad00\ud558\uac8c \uc0dd\ubb3c\uc744 \uc8fd\uc778\ub2e4. DNA\uc758 \uc5ec\ub7ec \ubd80\uc704\uac00 \ub04a\uae30\ub294 \uac83\ucc98\ub7fc \uc138\ud3ec \ub0b4\ubd80\uc5d0 \uadf9\uc2ec\ud55c \uc2a4\ud2b8\ub808\uc2a4 \uc0c1\ud669\uc774 \ubc1c\uc0dd\ud558\uba74 \ubcf5\uad6c\ud558\uae30 \uc5b4\ub835\ub2e4. \uc774\ub85c \uc778\ud574 \ud544\uc5f0\uc801\uc73c\ub85c \ud6c4\uc131\uc720\uc804 \uc218\uc900\uc5d0\uc11c\ub294 \uc815\ubcf4 \uc0c1\uc2e4\uc774 \uc77c\uc5b4\ub09c\ub2e4.
\uc138\ud3ec\ub97c \uc190\uc0c1\uc2dc\ud0a4\uc9c0 \uc54a\uc73c\uba74\uc11c \uc7a5\uc218 \uc720\uc804\uc790\ub97c \ud65c\uc131\ud654\ud558\ub294 \ubc29\ubc95(hormesis\/\uc57d\ud55c \uc2a4\ud2b8\ub808\uc2a4\uc5d0 \ubc18\uc751\ud574 \ud65c\uc131\uc744 \ub744\ub294 \ud604\uc0c1) : \uace0\uc628\uacfc \uc800\uc628 \ub178\ucd9c, \uac04\ud5d0\uc801 \ub2e8\uc2dd, \uc800\ub2e8\ubc31\uc9c8 \uc2dd\ub2e8, \uc6b4\ub3d9.<\/p>\n\n\n\n

“\ub178\ud654 \uc720\uc804\uc790”\ub294 \uc5c6\ub2e4!
\uc554\uc744 \uce58\ub8cc\ud558\uae30 \uc704\ud55c \uc8fc\uc694 \ud45c\uc801\uc774 \ub418\ub294 “\uc885\uc591 \uc720\uc804\uc790”\uc640\ub294 \ub2ec\ub9ac, \ub178\ud654\ub97c \uc77c\uc73c\ud0a4\ub294 \uc720\uc804\uc790\ub294 \uc5c6\ub2e4. \uc6b0\ub9ac \uc720\uc804\uc790\ub294 \ub178\ud654\ub97c \uc77c\uc73c\ud0a4\ub3c4\ub85d \uc9c4\ud654\ud558\uc9c0 \uc54a\uc558\uae30 \ub54c\ubb38\uc774\ub2e4.
\uc774\ud6c4 \ud6a8\ubaa8\uc5d0 \ub300\ud55c \uc774\uc57c\uae30, \uc790\uae30\uc758 \uc5f0\uad6c \uc774\uc57c\uae30 \ub4f1 \ud765\ubbf8\ub86d\uace0 \ucc45\uc744 \uacc4\uc18d \uc77d\uac8c \ub9cc\ub4dc\ub294 \ub0b4\uc6a9\uc774 \ub4f1\uc7a5\ud55c\ub2e4. \ud6a8\ubaa8\ub85c \ub178\ud654\uc758 \ube44\ubc00\uc744 \ud30c\ud5e4\uce58\ub824\ub294 \uc791\uac00\uc758 \uc774\uc57c\uae30\ub2e4.
\ud6c4\uc131\uc720\uc804\uccb4\ub294 \ud788\uc2a4\ud1a4\ub2e8\ubc31\uc9c8\uc744 DNA\uac00 \uac10\uc2f8\uace0 \uc788\ub294 \ud615\ud0dc\ub2e4. \uc774 \uac00\ub2e5\uc774 \uac10\uaca8\uc11c \uc5fc\uc0c9\uc9c8\uc744, \uc5fc\uc0c9\uc9c8\uc774 \uac10\uaca8\uc11c \uc5fc\uc0c9\uccb4\ub97c \uc774\ub8ec\ub2e4. \uc11c\ud22c\uc778\uc740 \ud788\uc2a4\ud1a4\uc5d0\uac8c DNA\uc640 \uaf49 \uacb0\ud569\ud558\ub77c\uace0 \uc9c0\uc2dc\ud55c\ub2e4. \ub610\ud55c \uc6d0\ub798 \uc790\ub9ac\ub97c \ub5a0\ub098 \ub3cc\uc544\ub2e4\ub2c8\uae30\ub3c4 \ud55c\ub2e4. \uc774\ub807\uac8c \ud568\uc73c\ub85c\uc368 \uc720\uc804\uc790\ub97c \ucf1c\uace0 \ub048\ub2e4. \uc5b4\ub5a4 \uc720\uc804\uc790\uc5d0 DNA\uacb0\ud569 \uc804\uc0ac \uc778\uc790DNA-binding transcription factor\uac00 \ub2ec\ub77c\ubd99\uc73c\uba74 \ucf1c\uc9c4\ub2e4. \uc804\uc0ac \uc778\uc790\uac00 \ub2ec\ub77c\ubd99\uc744 \uc218 \uc788\ub294 \ubd80\uc704\ub294 \uc9c4\uc815\uc5fc\uc0c9\uc9c8 euchromatin, \ubabb \ub2ec\ub77c\ubd99\ub294(silencing) \ubd80\uc704\ub294 \uc774\uc9c8\uc5fc\uc0c9\uc9c8 heterochromatin\uc774\ub2e4. \uc11c\ud22c\uc778\uc740 \ud788\uc2a4\ud1a4\uc5d0 \ubd99\uc740 \ud654\ud559\uc801 \uaf2c\ub9ac\ud45c(\uc544\uc138\ud2f8\uae30)\ub97c \uc81c\uac70\ud568\uc73c\ub85c\uc368 \uc804\uc0ac \uc778\uc790\uac00 \uc720\uc804\uc790\uc5d0 \ub2ec\ub77c\ubd99\uc9c0 \ubabb\ud558\uac8c \ub9c9\uc74c\uc73c\ub85c\uc368 \uc720\uc804\uc790\ub97c \ub048\ub2e4.
\ub3d9\uc77c\ud55c DNA\ub97c \uac16\uace0 \uc788\ub294 \uc6b0\ub9ac\uc758 \uc138\ud3ec\uac00, \uac01\uae30 \ub2e4\ub978 \uae30\uad00\uc5d0\uc11c \ub2e4\ub978 \uc5ed\ud560\uc744 \ud560 \uc218 \uc788\uac8c  \ubd84\ud654\ud558\ub3c4\ub85d \uc870\uc728\ud558\ub294 \uac8c \uc774 \ud6c4\uc131\uc720\uc804\uccb4\ub2e4. (\uc791\uac00\ub294 \uc774\ub97c \ud53c\uc544\ub178 \uc5f0\uc8fc\uc5d0 \ube44\uc720\ud588\ub2e4. \uc218 \ub9ce\uc740 \uac74\ubc18\uc758 \uc870\ud569\uc73c\ub85c \uc74c\uc545\uc744 \ub9cc\ub4e4\uc5b4\ub0b4\ub294) \uc5f0\uc8fc\uc790(\ud6c4\uc131\uc720\uc804\uccb4)\uac00 \uc5f0\uc8fc\ub97c \ud558\ub2e4\uac00 \uac74\ubc18 \ud558\ub098\ub97c \uc798\ubabb \ub204\ub978\ub2e4. \uc544\ubb34\ub3c4 \uc54c\uc544\ucc28\ub9ac\uc9c0 \ubabb\ud55c\ub2e4. \uadf8\ub7ec\ub098 \uc810\uc810 \ube48\ub3c4\uac00 \ub294\ub2e4. \ud53c\uc544\ub178\uc5d0\ub294 \uc544\ubb34\ub7f0 \ubb38\uc81c\uac00 \uc5c6\uace0, \ud53c\uc544\ub2c8\uc2a4\ud2b8\ub294 \uc791\uace1\uac00\uac00 \uc9c0\uc815\ud55c \uc74c\uc744 ‘\uac70\uc758 \ub2e4’ \uc5f0\uc8fc\ud558\uace0 \uc788\uc73c\ub098, \uc77c\ubd80 \uc74c\uc744 \ucd94\uac00\ub85c \uc5f0\uc8fc\ud558\uace0 \uc788\ub2e4. \uc2dc\uac04\uc774 \ud750\ub974\uba74\uc11c \uc5f0\uc8fc\ud68c\ub294 \uc5c9\ub9dd\uc774 \ub418\uae30 \uc2dc\uc791\ud55c\ub2e4.
\uc774\uac8c \ubc14\ub85c \ub178\ud654\ub2e4. \ud53c\uc544\ub178\ub294 DNA,\uba40\uca61\ud558\ub2e4. \ud6c4\uc131\uc720\uc804\uccb4\uac00 \uc720\uc804\uc790\ub97c \ucf1c\uace0 \ub044\ub294 \uacfc\uc815\uc5d0\uc11c \ubb54\uac00 \uc7a1\uc74c\uc774 \ubc1c\uc0dd\ud558\uace0 ,\uc774\ub7f0 \ud63c\ub780\uc740 \ub300\ubd80\ubd84 DNA\uac00 \ub04a\uae30\ub294 \uc77c\ucc98\ub7fc \uc138\ud3ec\uc5d0 \uc2ec\ud55c \uc190\uc0c1\uc774 \uc77c\uc5b4\ub0a8\uc73c\ub85c\uc368 \uc0dd\uae34\ub2e4. \uc774\ub7ec\ud55c \uc7a1\uc74c\uc774 \uc6b0\ub9ac\uac00 \ub299\ub294 \uc774\uc720\ub2e4.
\ub178\ud654\uc758 \ubcf4\ud3b8\uc801\uc778 \ubaa8\ud615\uc740 \ub2e4\uc74c\uacfc \uac19\ub2e4 : \uc80a\uc74c – DNA\ub04a\uae40 – \uc720\uc804\uccb4 \ubd88\uc548\uc815- DNA \ud3ec\uc7a5\uacfc \uc720\uc804\uc790 \uc870\uc808\uc758 \uad50\ub780 – \uc138\ud3ec \uc815\uccb4\uc131 \uc0c1\uc2e4- \uc138\ud3ec \ub178\ud654 – \uc9c8\ubcd1- \uc8fd\uc74c
\uc6b0\ub9ac\uc758 DNA\ub294 \ub04a\uc784\uc5c6\uc774 \ub04a\uae34\ub2e4. \uc138\ud3ec\uac00 \ubcf5\uc81c\ud560 \ub54c\ub9c8\ub2e4 \uc5b4\ub5a4 \uc2dd\uc73c\ub85c\ub4e0 \ub04a\uae30\uba70, \uc790\uc5f0 \ubc29\uc0ac\uc120, \ud658\uacbd\uc758 \ud654\ud559 \ubb3c\uc9c8, \ubcd1\uc6d0\uc758 \uc5d1\uc2a4\uc120 \ucd2c\uc601\uc5d0\ub3c4\ub04a\uae34\ub2e4. DNA\uac00 \ub04a\uae30\uba74 \uc11c\ud22c\uc778\uc774 DNA\uc218\uc120\uc758 \uc5ed\ud560\uc744 \ud558\uae30 \uc704\ud574 \ub5a0\ub098\uc11c \ub2e4\ub978 \uc5c5\ubb34(DNA \uc548\uc815, \uc138\ud3ec \uc0dd\uc874, \ub300\uc0ac, \uc138\ud3ec \uac04 \uc758\uc0ac\uc18c\ud1b5 \ub4f1)\ub97c \ud558\uc9c0 \ubabb\ud55c\ub2e4. DNA\uac00 \uc790\uc8fc \ub04a\uae38\uc218\ub85d, DNA \uc218\uc120\uc5d0 \uc9d1\uc911\ud574\uc57c \ud558\uae30\uc5d0 \ubcf8\uc5f0\uc758 \ud6c4\uc131\uc720\uc804\uc801 \uae30\ub2a5\uc740 \uc624\ub798 \uc911\ub2e8\ud560 \uc218 \ubc16\uc5d0 \uc5c6\ub2e4.  \ubb38\uc81c\ub294 \uc11c\ud22c\uc778 \ub2e8\ubc31\uc9c8\uc774 \uc6d0\ub798 \uc788\ub358 \uacf3\uc73c\ub85c \ub3cc\uc544\uac00\uc9c0 \uc54a\uc73c\uba74\uc11c \uc77c\uc5b4\ub09c\ub2e4. \uc11c\ud22c\uc778 \ub2e8\ubc31\uc9c8\uc774 \uc6d0\ub798\uc758 \uc720\uc804\uc790\ub97c \ub5a0\ub098\uba74\uc11c \ucf1c\uc84c\ub358 \uc720\uc804\uc790\ub294 \uaebc\uc9c0\uace0 \uaebc\uc84c\ub358 \uc720\uc804\uc790\ub294 \ucf1c\uc9c4\ub2e4. \uadf8\ub9ac\uace0 \ub2e4\uc2dc \uacb0\ud569\ud560 \ub54c\ub294 \ubc18\ub300\uc758 \ud604\uc0c1\uc774 \uc77c\uc5b4\ub09c\ub2e4. \uadf8\ub7ec\uba74\uc11c \uc6b0\ub9ac\uac00 \uc758\ub3c4\ud558\uc9c0 \uc54a\uc558\ub358 \ubc29\uc2dd\uc73c\ub85c \uc720\uc804\uccb4\ub97c \ubc14\uafbc\ub2e4. \uc774\uac83\uc774 \ud6c4\uc131\uc720\uc804\uc801 \uc7a1\uc74c\uc774\ub2e4.
\uc0dd\uc874\ud68c\ub85c\uac00 \uc791\ub3d9\ud558\uace0 \ub178\ud654\uac00 \uc77c\uc5b4\ub098\ub824\uba74 \uc11c\ud22c\uc778 \ub2e8\ubc31\uc9c8\uacfc \uac19\uc740 \ud6c4\uc131\uc720\uc804\uc801 \uc870\uc808 \uc778\uc790\ub4e4\uc774 \ud55c\uc815\ub41c \uc591\uc73c\ub85c \uc874\uc7ac\ud574\uc57c \ud55c\ub2e4. \uadf8\ub798\uc11c \ub04a\uae34 \uc720\uc804\uc790\ub97c \uc218\uc120\ud558\uba74\uc11c \ub3d9\uc2dc\uc5d0 \ub2e4\ub978 \uc720\uc804\uc790\ub97c \uce68\ubb35\uc2dc\ud0a4\ub294 \uc77c\uc774 \uc77c\uc5b4\ub098\uba74 \uc548 \ub41c\ub2e4. \uadf8\ub807\uae30\uc5d0 SIR2 \uc720\uc804\uc790\uc758 \uc0ac\ubcf8\uc744 \ucd94\uac00\ud558\uba74 \uc218\uba85\uc774 \ub298\uace0 \ub354 \uc624\ub798 \ubc88\uc2dd\ud560 \uc218 \uc788\ub2e4. \uc9c4\ud654\uc801\uc73c\ub85c \uc720\ub9ac\ud558\uc9c0 \uc54a\uc558\uae30\uc5d0 \uc774\ub294 \uc790\uc5f0\uc120\ud0dd\uc5d0\uc11c \ubc30\uc81c\ub418\uc5c8\ub2e4. \uc11c\ud22c\uc778\uc740 \uc5d0\ub108\uc9c0\ub97c \ub9ce\uc774 \uc4f0\uae30\uc5d0 \uc0dd\uc874\uc5d0\uc11c \ubd88\ub9ac\ud558\uae30\uae4c\uc9c0 \ud558\ub2e4.
\uc18c\ub098\ubb34\ub294 \uc6b0\ub9ac\uc758 \uc9c4\ud575 \uc138\ud3ec \uc0ac\ucd0c\uc778\ub370, \uadf8\ub4e4\uc740 \ub299\uc9c0 \uc54a\ub294\ub2e4. \uc80a\uc740 \uc18c\ub098\ubb34\uc640 \ub299\uc740 \uc18c\ub098\ubb34\ub294 \uc5b4\ub5a0\ud55c \uc758\ubbf8 \uc788\ub294 \ucc28\uc774\ub3c4 \uc5c6\ub2e4. \ud574\ud30c\ub9ac \uc911 \uc77c\ubd80\ub294 \uc798\ub824 \ub098\uac04 \uc2e0\uccb4 \ubd80\uc704\ub85c\ubd80\ud130 \uc628\uc804\ud788 \uc7ac\uc0dd\ud55c\ub2e4. \ud788\ub4dc\ub77c \uc5ed\uc2dc \ub299\uc9c0 \uc54a\ub294\ub2e4. \uadf8\ub9b0\ub780\ub4dc \uc0c1\uc5b4\ub294 150\uc138\uac00 \ub418\uc5b4\uc57c \uc131\uc801\uc73c\ub85c \uc131\uc219\ud55c\ub2e4. \ubd81\uadf9\uace0\ub798 \uc5ed\uc2dc \uc218\ubc31\ub144\uc744 \uc0b0\ub2e4. \uc138\ud3ec\uc758 \ub098\uc774\ub294 \uc644\uc804\ud788 \uc7ac\uc124\uc815\ub420 \uc218 \uc788\ub2e4. \uc6b0\ub9ac\ub294  \uc7a5\uc218 \uc720\uc804\uc790 -FOXO1,3,4,6\uc744 \uac16\uace0 \uc788\uc74c.
\uc640\ub529\ud134\uc740 \ud6c4\uc131\uc720\uc804\uc801 \uacbd\uad00\uc774 \uc788\ub2e4\uace0 \uc0c1\uc0c1\ud588\ub2e4. \ubc30\uc544 \uc904\uae30\uc138\ud3ec\ub294 \uc0b0\uaf2d\ub300\uae30\uc5d0 \uc788\ub294 \uc870\uc57d\ub3cc\uc774\uace0, \uc774 \uc870\uc57d\ub3cc\uc774 \uad74\ub7ec \ub5a8\uc5b4\uc838\uc11c \uc218\ubc31 \uac1c\uc758 \uace8\uc9dc\uae30\uc911 \ud558\ub098\ub85c \ub5a8\uc5b4\uc9c4\ub2e4. \uc774\ub97c ‘\ubd84\ud654’\ub77c\uace0 \ud55c\ub2e4. \ud6c4\uc131\uc720\uc804\uccb4\ub294 \uc911\ub825\uc758 \uc5ed\ud560\uc744 \ud55c\ub2e4. \uadf8 \uc870\uc57d\ub3cc\uc774 \uadf8 \uace8\uc9dc\uae30\uc5d0 \uc788\ub3c4\ub85d \uc720\uc9c0\ud558\ub294 \uc5ed\ud560\uc774\uc790, \uadf8 \uc870\uc57d\ub3cc\uc744 \ubc11\uc73c\ub85c \ub04c\uc5b4\ub2f9\uae30\ub294 \uc5ed\ud560.
\uacfc\ud559\uc801\uc73c\ub85c \uc124\uba85\ud558\uba74 \ub2e4\uc74c\uacfc \uac19\ub2e4. \uc11c\ud22c\uc778\uacfc \uc804\uc0ac\uc778\uc790, DNMT, HMT \ub4f1\uc758 \uc548\ub0b4\uc5d0 \ub530\ub77c \uac01 \uc720\uc804\uc790\ub4e4\uc774 \ub2e4\ub978 \ubc29\uc2dd\uc73c\ub85c \ucf1c\uc9c0\uace0 \uaebc\uc9d0\uc73c\ub85c\uc368 \ub2e4\ub978 \uc138\ud3ec\ub85c \ubd84\ud654\ud55c\ub2e4.
\uc774 \uc815\ubcf4\uc758 \uc548\uc815\uc131\uc774 \uc6b0\ub9ac\uc758 \uac74\uac15\uc5d0 \uc544\uc8fc \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4. DNA\uc5d0 \uc190\uc0c1\uc774 \uc77c\uc5b4\ub0a0 \ub54c\ub9c8\ub2e4 \uc870\uc57d\ub3cc\uc740 \ub4e4\uc369\uac70\ub9b0\ub2e4. \uc2dc\uac04\uc774 \uc9c0\ub098\uba74\uc11c \uace8\uc9dc\uae30\uac00 \uc595\uc544\uc9d0\uc5d0 \ub530\ub77c \uc870\uc57d\ub3cc\uc774 \ub4e4\uc369\uac70\ub9b4 \ub54c \uc0c8\ub85c\uc6b4 \uace8\uc9dc\uae30\ub85c \ub4e4\uc5b4\uac00\ub294 \uc77c\uc774 \uc0dd\uae34\ub2e4. \uadf8\ub807\uac8c \uac01 \uc138\ud3ec\ub294 \uc7a1\uc74c\uc5d0 \uad74\ubcf5\ud55c\ub2e4. 
\uccb4\ub0b4 NAD \ub18d\ub3c4\uac00 \uc99d\uac00\ud558\uba74 \uc11c\ud22c\uc778 \ud65c\uc131\uc774 \uc99d\uac00\ud55c\ub2e4. NAD \ub18d\ub3c4\uac00 \uc99d\uac00\ud55c \uc0dd\uc950\ub4e4\uc740 \ud2b8\ub808\ub4dc\ubc00\uc774 \ubd80\uc11c\uc9c8 \ub54c\uae4c\uc9c0 \uac8c\uc18d \ub2ec\ub838\ub2e4.<\/p>\n\n\n\n

\ub178\ud654\ub294 \uc9c8\ubcd1\uc774\ub2e4. \ub299\uc5b4\uc11c \uc8fd\ub294 \uc0ac\ub78c\uc740 \uc5c6\ub2e4. \ub299\uc5b4\uc11c \uc5b4\ub518\uac00\uc5d0 \uc9c8\ubcd1\uc774 \uc0dd\uaca8\uc11c \uc8fd\ub294\ub2e4. \uadf8\ub7f0\ub370 \uc6b0\ub9ac\ub294 \uac1c\ubcc4\uc801\uc778 \uc9c8\ubcd1\uc758 \uce58\ub8cc\uc5d0\ub9cc \ucd08\uc810\uc744 \ub9de\ucd94\uc9c0, \ub178\ud654 \uc790\uccb4\ub97c \uc9c8\ubcd1\uc73c\ub85c \ubcfc \uc0dd\uac01\uc740 \uc9c0\uae08\uae4c\uc9c0 \ud558\uc9c0 \ubabb\ud588\uc74c. [\uc791\uac00\ub294 \ub178\ud654\ub294 \uc9c8\ubcd1\uc774\uace0, \uc6b0\ub9ac\ub294 \uc774\ub97c \uce58\ub8cc\ud560 \uc218 \uc788\ub2e4\uace0 \uac15\ud558\uac8c \uc8fc\uc7a5\ud55c\ub2e4. \uadf8\ub9ac\uace0 \ub098 \uc5ed\uc2dc \uadf8\uac00 \uc633\uae30\ub97c \uac04\uc808\ud788 \uc18c\ub9dd\ud55c\ub2e4.]























<\/p>\n\n\n\n
























<\/p>\n","protected":false},"excerpt":{"rendered":"

\ub178\ud654\uc758 \uc885\ub9d0 – \ub370\uc774\ube44\ub4dc \uc2f1\ud074\ub808\uc5b4@ \uae30\ubd84 \uc88b\uc740 \ucda9\uaca9\uc744 \uc120\uc0ac\ud558\ub294 \ucc45\uc774\ub2e4. \ub2f9\uc5f0\ud558\uac8c \uc0dd\uac01\ud588\ub358 ‘\ub178\ud654’\uc5d0 \ub300\ud55c \uc0dd\uac01\uc744 \ubc14\uafb8\uac8c \ub410\ub2e4. \ub299\uace0 \ubcd1\ub4e4\uc5b4 \uac00\ub294 \uac74 \ub2f9\uc5f0\ud55c \uc77c\uc774\ub77c\uace0 \uc0dd\uac01\ud588\ub294\ub370, \uc0dd\uac01\ubcf4\ub2e4 \uc608\ubc29\ud560 \ubc29\ubc95\uc774 \ub9ce\ub2e4\uace0 \ub290\uaf08\ub2e4. \uc544\uc9c1 \uc80a\uc740 \ub0a0\uc5d0 \uc774\ub7f0 \uae00\uc744 \uc77d\uac8c \ub418\uc5c8\uc74c\uc5d0 \uac10\uc0ac\ud55c\ub2e4.\uac00\uc7a5 \ucda9\uaca9\uc801\uc778 \ubd80\ubd84\uc740 \ub178\ud654\uc758 \uc774\ub860\uc774\uc5c8\ub2e4. \uc138\ud3ec\uac00 \ubcf5\uc81c\ub418\uba74\uc11c \uc77c\uc5b4\ub098\ub294 \uc815\ubcf4\uc758 \uc190\uc2e4 \ub54c\ubb38\uc5d0 \ub299\ub294\ub2e4\ub294 \uc0ac\uc2e4. \uadf8\uac83\uc744 \uc6d0\ucd08\uc9c1\uc778 \uc720\uc804\uc790 A\uc640 \uc720\uc804\uc790 B\ub85c … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-315","post","type-post","status-publish","format-standard","hentry","category-1"],"_links":{"self":[{"href":"https:\/\/mors01.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mors01.co.kr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mors01.co.kr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mors01.co.kr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mors01.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=315"}],"version-history":[{"count":1,"href":"https:\/\/mors01.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/315\/revisions"}],"predecessor-version":[{"id":316,"href":"https:\/\/mors01.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/315\/revisions\/316"}],"wp:attachment":[{"href":"https:\/\/mors01.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=315"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mors01.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=315"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mors01.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}